2-(4-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid acid tert-butyl ester

Base Information

• Chemical Name: 2-(4-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid acid tert-butyl ester
• CAS No.: 1352718-88-7
• Molecular Formula: C₁₂H₁₈BrN₃O₂
• Molecular Weight: 316.198

Synonyms:2-(4-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid acid tert-butyl ester

Chemical Property of 2-(4-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid acid tert-butyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl2-(5-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylate 95%+ ^*data from reagent suppliers

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Technology Process of 2-(4-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid acid tert-butyl ester

There total 8 articles about 2-(4-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

(S) 2-(4,5-dibromo-1H-imidazol-2-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester + 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran (96042-30-7) → 2-(4-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid acid tert-butyl ester (1352718-88-7)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; methanol; hexane; water; ethyl acetate;

Reference yield:

(S) 2-(4,5-dibromo-1H-imidazol-2-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester → tert-butyl 2-(5-bromo-1H-imidazol-2-yl) pyrrolidine-1-carboxylate (1352718-88-7)

Guidance literature:

With sodium sulfite; In 1,4-dioxane; dichloromethane; water;

Reference yield:

(S) 2-(1H-imidazol-2-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester (1352719-15-3,1332326-40-5) → 2-(4-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid acid tert-butyl ester (1352718-88-7)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane

2: n-butyllithium / ethyl acetate; hexane; water; tetrahydrofuran; methanol

With n-butyllithium; In tetrahydrofuran; methanol; hexane; dichloromethane; water; ethyl acetate;

upstream raw materials:

4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

(S) 2-(1H-imidazol-2-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Boc-L-Pro-H

N-Boc-prolinol

Downstream raw materials:

[(S)-1-((S)-2-{4-[4-(6-{2-[(S)-1-((S)-2-methoxycarbonylamino-3-methylbutyryl)pyrrolidin-2-yl]-3H-imidazol-4-yl}thieno[3,2-b]thiophen-3-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carbonyl)-2-methylpropyl]carbamicacid methyl ester

(S)-2-{5-[6-(4-{2-[(S)-1-((S)-2-methoxycarbonylamino-3-methylbutyryl)pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)thieno[3,2-b]thiophen-3-yl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylic acid tert-butyl ester

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