1-methyl-4-oxo-(2E)-pentenyl N-benzyl-[(2E)-buteno]hydroxamate

Base Information

• Chemical Name: 1-methyl-4-oxo-(2E)-pentenyl N-benzyl-[(2E)-buteno]hydroxamate
• CAS No.: 346718-05-6
• Molecular Formula: C₁₇H₂₁NO₃
• Molecular Weight: 287.359
• Mol file: 346718-05-6.mol

Synonyms:1-methyl-4-oxo-(2E)-pentenyl N-benzyl-[(2E)-buteno]hydroxamate

Chemical Property of 1-methyl-4-oxo-(2E)-pentenyl N-benzyl-[(2E)-buteno]hydroxamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-methyl-4-oxo-(2E)-pentenyl N-benzyl-[(2E)-buteno]hydroxamate

There total 1 articles about 1-methyl-4-oxo-(2E)-pentenyl N-benzyl-[(2E)-buteno]hydroxamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(E)-N-benzyl-N-hydroxybut-2-enamide + (E)-5-hydroxyhex-3-en-2-one (57204-67-8,288153-65-1) → 1-methyl-4-oxo-(2E)-pentenyl N-benzyl-[(2E)-buteno]hydroxamate (346718-05-6)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 4h;

DOI:10.1021/ja010083z

Reference yield:

t-butyldimethylsiyl triflate (69739-34-0) + 1-methyl-4-oxo-(2E)-pentenyl N-benzyl-[(2E)-buteno]hydroxamate (346718-05-6) → (E)-But-2-enoic acid benzyl-[(E)-4-(tert-butyl-dimethyl-silanyloxy)-1-methyl-penta-2,4-dienyloxy]-amide

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.166667h;

DOI:10.1021/ja010083z

Reference yield:

1-methyl-4-oxo-(2E)-pentenyl N-benzyl-[(2E)-buteno]hydroxamate (346718-05-6) → (1S,4aS,5R,8aR)-3-Benzyl-1,5-dimethyl-tetrahydro-benzo[d][1,2]oxazine-4,7-dione

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran / 0.17 h / 20 °C

2: toluene / 17 h / 90 °C

3: HCl / tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; triethylamine; In tetrahydrofuran; toluene;

DOI:10.1021/ja010083z

upstream raw materials:

(E)-5-hydroxyhex-3-en-2-one