methyl 5-amino-3,4-dihydro-7-methyl-3-(p-methylphenyl)-4-oxothieno<3,4-d>pyridazine-1-carboxylate

Base Information

• Chemical Name: methyl 5-amino-3,4-dihydro-7-methyl-3-(p-methylphenyl)-4-oxothieno<3,4-d>pyridazine-1-carboxylate
• CAS No.: 173537-82-1
• Molecular Formula: C₁₆H₁₅N₃O₃S
• Molecular Weight: 329.379

Synonyms:methyl 5-amino-3,4-dihydro-7-methyl-3-(p-methylphenyl)-4-oxothieno<3,4-d>pyridazine-1-carboxylate

Chemical Property of methyl 5-amino-3,4-dihydro-7-methyl-3-(p-methylphenyl)-4-oxothieno<3,4-d>pyridazine-1-carboxylate

Chemical Property:

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Technology Process of methyl 5-amino-3,4-dihydro-7-methyl-3-(p-methylphenyl)-4-oxothieno<3,4-d>pyridazine-1-carboxylate

There total 4 articles about methyl 5-amino-3,4-dihydro-7-methyl-3-(p-methylphenyl)-4-oxothieno<3,4-d>pyridazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

methyl 5-cyano-1,6-dihydro-4-ethyl-1-(p-methylphenyl)-6-oxopyridazine-3-carboxylate (173537-78-5) → methyl 5-amino-3,4-dihydro-7-methyl-3-(p-methylphenyl)-4-oxothieno<3,4-d>pyridazine-1-carboxylate (173537-82-1)

Guidance literature:

With sulfur; triethylamine; In 1,4-dioxane; for 3h; Heating;

DOI:10.1016/0040-4020(95)00829-W

Reference yield:

methyl propanoyl acetate (30414-53-0) → methyl 5-amino-3,4-dihydro-7-methyl-3-(p-methylphenyl)-4-oxothieno<3,4-d>pyridazine-1-carboxylate (173537-82-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / sodium acetate / ethanol / Ambient temperature

2: 81 percent / ammonium acetate, acetic acid / benzene / 6 h / Heating

3: 61 percent / sulfur, triethylamine / dioxane / 3 h / Heating

With ammonium acetate; sodium acetate; sulfur; acetic acid; triethylamine; In 1,4-dioxane; ethanol; benzene;

DOI:10.1016/0040-4020(95)00829-W

Reference yield:

p-methylbenzenediazonium chloride (2028-84-4) → methyl 5-amino-3,4-dihydro-7-methyl-3-(p-methylphenyl)-4-oxothieno<3,4-d>pyridazine-1-carboxylate (173537-82-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / sodium acetate / ethanol / Ambient temperature

2: 81 percent / ammonium acetate, acetic acid / benzene / 6 h / Heating

3: 61 percent / sulfur, triethylamine / dioxane / 3 h / Heating

With ammonium acetate; sodium acetate; sulfur; acetic acid; triethylamine; In 1,4-dioxane; ethanol; benzene;

DOI:10.1016/0040-4020(95)00829-W

upstream raw materials:

methyl 5-cyano-1,6-dihydro-4-ethyl-1-(p-methylphenyl)-6-oxopyridazine-3-carboxylate

methyl propanoyl acetate

p-methylbenzenediazonium chloride

Downstream raw materials:

methyl 5-[4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-3-oxobut-1-enylamino]-7-methyl-4-oxo-3-p-tolyl-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate

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