4-tert-butoxycarbonyl-1-[(4-chlorophenyl)aminothiocarbonyl]-2-methylpiperazine

Base Information

• Chemical Name: 4-tert-butoxycarbonyl-1-[(4-chlorophenyl)aminothiocarbonyl]-2-methylpiperazine
• CAS No.: 859154-52-2
• Molecular Formula: C₁₇H₂₄ClN₃O₂S
• Molecular Weight: 369.915
• Mol file: 859154-52-2.mol

Synonyms:4-tert-butoxycarbonyl-1-[(4-chlorophenyl)aminothiocarbonyl]-2-methylpiperazine

Chemical Property of 4-tert-butoxycarbonyl-1-[(4-chlorophenyl)aminothiocarbonyl]-2-methylpiperazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-tert-butoxycarbonyl-1-[(4-chlorophenyl)aminothiocarbonyl]-2-methylpiperazine

There total 2 articles about 4-tert-butoxycarbonyl-1-[(4-chlorophenyl)aminothiocarbonyl]-2-methylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

4-Chlorophenyl isothiocyanate (2131-55-7) + 3-methyl-piperazine-1-carboxylic acid tert-butyl ester (120737-59-9) → 4-tert-butoxycarbonyl-1-[(4-chlorophenyl)aminothiocarbonyl]-2-methylpiperazine (859154-52-2)

Guidance literature:

In dichloromethane; at 20 ℃;

DOI:10.1016/j.ejmech.2019.111840

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 4-tert-butoxycarbonyl-1-[(4-chlorophenyl)aminothiocarbonyl]-2-methylpiperazine (859154-52-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 12 h / 0 - 20 °C

2: dichloromethane / 20 °C

With pyridine; In dichloromethane;

DOI:10.1016/j.ejmech.2019.111840

upstream raw materials:

4-Chlorophenyl isothiocyanate

3-methyl-piperazine-1-carboxylic acid tert-butyl ester

di-tert-butyl dicarbonate