N-(3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)phenyl)-4-bromo-2-(trifluoromethoxy)benzenesulfonamide

Base Information

Chemical Name:N-(3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)phenyl)-4-bromo-2-(trifluoromethoxy)benzenesulfonamide
CAS No.:1365958-59-3
Molecular Formula:C₄₃H₃₁BrF₃NO₅S
Molecular Weight:810.688
Hs Code.:

Synonyms:N-(3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)phenyl)-4-bromo-2-(trifluoromethoxy)benzenesulfonamide

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Chemical Property of N-(3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)phenyl)-4-bromo-2-(trifluoromethoxy)benzenesulfonamide

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Technology Process of N-(3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)phenyl)-4-bromo-2-(trifluoromethoxy)benzenesulfonamide

There total 5 articles about N-(3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)phenyl)-4-bromo-2-(trifluoromethoxy)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 175278-14-5
4-bromo-2-(trifluoromethoxy)benzene-1-sulfonyl chloride

: 1365958-43-5
3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)aniline

: 1365958-59-3
N-(3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)phenyl)-4-bromo-2-(trifluoromethoxy)benzenesulfonamide

Guidance literature:: With pyridine; dmap; at 20 ℃; for 144h;
DOI:10.1021/jm201735j

Reference yield:

: 1365958-40-2
2-(benzyloxy)-6-(3-(benzyloxy)phenyl)-1-bromonaphthalene

: 1365958-59-3
N-(3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)phenyl)-4-bromo-2-(trifluoromethoxy)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,2-dimethoxyethane; ethanol; water / 0.25 h / 150 °C / 1125.11 Torr / Microwave irradiation

2: pyridine; dmap / 144 h / 20 °C

With pyridine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,2-dimethoxyethane; ethanol; water; 1: Suzuki coupling;
DOI:10.1021/jm201735j

Reference yield:

: 16239-18-2
1,6-dibromo-2-naphthol

: 1365958-59-3
N-(3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)phenyl)-4-bromo-2-(trifluoromethoxy)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / ethanol / 15 h / Inert atmosphere; Reflux

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / tetrahydrofuran; water / 4 h / Reflux

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,2-dimethoxyethane; ethanol; water / 0.25 h / 150 °C / 1125.11 Torr / Microwave irradiation

4: pyridine; dmap / 144 h / 20 °C

With pyridine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; caesium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; 2: Suzuki coupling / 3: Suzuki coupling;
DOI:10.1021/jm201735j