(3R,5R)-7-[3-(4-fluoro-phenyl)-1-isopropyl-5-(4-methoxy-benzylcarbamoyl)-4-phenyl-1H-pyrrol-2-yl]-3,5-dihydroxy-heptanoic acid tert-butyl ester

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Chemical Name:(3R,5R)-7-[3-(4-fluoro-phenyl)-1-isopropyl-5-(4-methoxy-benzylcarbamoyl)-4-phenyl-1H-pyrrol-2-yl]-3,5-dihydroxy-heptanoic acid tert-butyl ester
CAS No.:855249-04-6
Molecular Formula:C₃₉H₄₇FN₂O₆
Molecular Weight:658.81
Hs Code.:

Synonyms:(3R,5R)-7-[3-(4-fluoro-phenyl)-1-isopropyl-5-(4-methoxy-benzylcarbamoyl)-4-phenyl-1H-pyrrol-2-yl]-3,5-dihydroxy-heptanoic acid tert-butyl ester

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Chemical Property of (3R,5R)-7-[3-(4-fluoro-phenyl)-1-isopropyl-5-(4-methoxy-benzylcarbamoyl)-4-phenyl-1H-pyrrol-2-yl]-3,5-dihydroxy-heptanoic acid tert-butyl ester

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Technology Process of (3R,5R)-7-[3-(4-fluoro-phenyl)-1-isopropyl-5-(4-methoxy-benzylcarbamoyl)-4-phenyl-1H-pyrrol-2-yl]-3,5-dihydroxy-heptanoic acid tert-butyl ester

There total 16 articles about (3R,5R)-7-[3-(4-fluoro-phenyl)-1-isopropyl-5-(4-methoxy-benzylcarbamoyl)-4-phenyl-1H-pyrrol-2-yl]-3,5-dihydroxy-heptanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 855249-03-5
(6-{2-[3-(4-fluorophenyl)-1-isopropyl-5-(4-methoxybenzylcarbamoyl)-4-phenyl-1H-pyrrol-2-yl]vinyl}-2,2-dimethyl-[1,3]dioxan-4-yl)acetic acid tert-butyl ester

: 855249-04-6
(3R,5R)-7-[3-(4-fluoro-phenyl)-1-isopropyl-5-(4-methoxy-benzylcarbamoyl)-4-phenyl-1H-pyrrol-2-yl]-3,5-dihydroxy-heptanoic acid tert-butyl ester

Guidance literature:: (6-{2-[3-(4-fluorophenyl)-1-isopropyl-5-(4-methoxybenzylcarbamoyl)-4-phenyl-1H-pyrrol-2-yl]vinyl}-2,2-dimethyl-[1,3]dioxan-4-yl)acetic acid tert-butyl ester; With hydrogen; palladium 10% on activated carbon; In methanol; for 3h; under 2585.81 Torr;

With water; hydrogenchloride; In methanol; at 25 ℃; for 3h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: C₄₂H₅₁FN₂O₆

: 855249-04-6
(3R,5R)-7-[3-(4-fluoro-phenyl)-1-isopropyl-5-(4-methoxy-benzylcarbamoyl)-4-phenyl-1H-pyrrol-2-yl]-3,5-dihydroxy-heptanoic acid tert-butyl ester

Guidance literature:: With hydrogenchloride; In methanol; at 25 ℃; for 3h;
DOI:10.1016/j.tet.2007.06.005

Reference yield:

: 3-dimethylamino-2-(4-fluoro-phenyl)-1-phenylpropenone

: 855249-04-6
(3R,5R)-7-[3-(4-fluoro-phenyl)-1-isopropyl-5-(4-methoxy-benzylcarbamoyl)-4-phenyl-1H-pyrrol-2-yl]-3,5-dihydroxy-heptanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 85 percent / glacial acetic acid / 2 h / 120 °C

2: phosphorus oxychloride / 1,2-dichloro-ethane / 18 h / 80 °C

3: 498 g / aq. sodium hydroxide / tetrahydrofuran; methanol / 24 h / 25 °C

4: thionyl chloride / 2 h / 75 °C

5: 11.14 g / triethylamine / CH₂Cl₂ / 2 h / 0 °C

6: 41 percent / lithium tri-tert-butoxyaluminohydride / tetrahydrofuran / 0.5 h / 0 °C

7: 100 percent / CH₂Cl₂ / 2.5 h / 50 °C

8: 75 percent / NaHMDS / tetrahydrofuran / 2 h / -78 - 25 °C

9: hydrogen / Pd/C / methanol / 3 h / 25 °C / 2585.81 Torr

10: 3.74 g / aq. HCl / methanol / 3 h / 25 °C

With hydrogenchloride; sodium hydroxide; thionyl chloride; lithium tri(t-butoxy)aluminum hydride; hydrogen; sodium hexamethyldisilazane; acetic acid; triethylamine; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; 2: Vilsmeier-Haack reaction / 8: Wittig olefination;
DOI:10.1016/j.tet.2007.06.005