(2S,3aR,5R,6S,7aS)-6-acetoxy-1-((S)-2-((S)-2-(benzyloxy)-3-(4-(benzyloxy)phenyl)propanamido)-3-phenylpropanoyl)-2-(4-(tert-butyldiphenylsilyloxy)butylcarbamoyl)octahydro-1H-indol-5-yl 3-(trifluoromethyl)benzoate

Base Information

Chemical Name:(2S,3aR,5R,6S,7aS)-6-acetoxy-1-((S)-2-((S)-2-(benzyloxy)-3-(4-(benzyloxy)phenyl)propanamido)-3-phenylpropanoyl)-2-(4-(tert-butyldiphenylsilyloxy)butylcarbamoyl)octahydro-1H-indol-5-yl 3-(trifluoromethyl)benzoate
CAS No.:1242104-23-9
Molecular Formula:C₇₁H₇₆F₃N₃O₁₀Si
Molecular Weight:1216.48
Hs Code.:

(2S,3aR,5R,6S,7aS)-6-acetoxy-1-((S)-2-((S)-2-(benzyloxy)-3-(4-(benzyloxy)phenyl)propanamido)-3-phenylpropanoyl)-2-(4-(tert-butyldiphenylsilyloxy)butylcarbamoyl)octahydro-1H-indol-5-yl 3-(trifluoromethyl)benzoate

Synonyms:(2S,3aR,5R,6S,7aS)-6-acetoxy-1-((S)-2-((S)-2-(benzyloxy)-3-(4-(benzyloxy)phenyl)propanamido)-3-phenylpropanoyl)-2-(4-(tert-butyldiphenylsilyloxy)butylcarbamoyl)octahydro-1H-indol-5-yl 3-(trifluoromethyl)benzoate

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Chemical Property of (2S,3aR,5R,6S,7aS)-6-acetoxy-1-((S)-2-((S)-2-(benzyloxy)-3-(4-(benzyloxy)phenyl)propanamido)-3-phenylpropanoyl)-2-(4-(tert-butyldiphenylsilyloxy)butylcarbamoyl)octahydro-1H-indol-5-yl 3-(trifluoromethyl)benzoate

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Technology Process of (2S,3aR,5R,6S,7aS)-6-acetoxy-1-((S)-2-((S)-2-(benzyloxy)-3-(4-(benzyloxy)phenyl)propanamido)-3-phenylpropanoyl)-2-(4-(tert-butyldiphenylsilyloxy)butylcarbamoyl)octahydro-1H-indol-5-yl 3-(trifluoromethyl)benzoate

There total 23 articles about (2S,3aR,5R,6S,7aS)-6-acetoxy-1-((S)-2-((S)-2-(benzyloxy)-3-(4-(benzyloxy)phenyl)propanamido)-3-phenylpropanoyl)-2-(4-(tert-butyldiphenylsilyloxy)butylcarbamoyl)octahydro-1H-indol-5-yl 3-(trifluoromethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: (2S,3aR,5R,6S,7aS)-1-(2-((S)-2-(benzyloxy)-3-(4-(benzyloxy)phenyl)propanamido)-3-phenylpropanoyl)-2-(4-(tert-butyldiphenylsilyloxy)butylcarbamoyl)-5-hydroxyoctahydro-1H-indol-6-yl acetate

: 2251-65-2
3-(Trifluoromethyl)benzoyl chloride

: 1242104-23-9
(2S,3aR,5R,6S,7aS)-6-acetoxy-1-((S)-2-((S)-2-(benzyloxy)-3-(4-(benzyloxy)phenyl)propanamido)-3-phenylpropanoyl)-2-(4-(tert-butyldiphenylsilyloxy)butylcarbamoyl)octahydro-1H-indol-5-yl 3-(trifluoromethyl)benzoate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/ol1017189

Reference yield: 59.0%

: 1242104-16-0
(2S,3aR,5R,6S,7aS)-1-((S)-2-((S)-2-(benzyloxy)-3-(4-(benzyloxy)phenyl)propanamido)-3-phenylpropanoyl)-2-(4-(tert-butyldiphenylsilyloxy)butylcarbamoyl)-5-hydroxyoctahydro-1H-indol-6-yl acetate

: 2251-65-2
3-(Trifluoromethyl)benzoyl chloride

: 1242104-23-9
(2S,3aR,5R,6S,7aS)-6-acetoxy-1-((S)-2-((S)-2-(benzyloxy)-3-(4-(benzyloxy)phenyl)propanamido)-3-phenylpropanoyl)-2-(4-(tert-butyldiphenylsilyloxy)butylcarbamoyl)octahydro-1H-indol-5-yl 3-(trifluoromethyl)benzoate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1002/chem.201400046

Reference yield:

: 1621925-46-9
C₃₇H₆₀N₂O₅Si₃

: 1242104-23-9
(2S,3aR,5R,6S,7aS)-6-acetoxy-1-((S)-2-((S)-2-(benzyloxy)-3-(4-(benzyloxy)phenyl)propanamido)-3-phenylpropanoyl)-2-(4-(tert-butyldiphenylsilyloxy)butylcarbamoyl)octahydro-1H-indol-5-yl 3-(trifluoromethyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; fluorosilicic acid / water; acetonitrile / 12.5 h / 20 - 65 °C

2: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

3: triethylamine; dmap / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

With dmap; fluorosilicic acid; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; water; acetonitrile;
DOI:10.1002/chem.201400046