methyl 2,2-difluoro-3-phenylcyclopropyl ketone

Base Information

Chemical Name:methyl 2,2-difluoro-3-phenylcyclopropyl ketone
CAS No.:82045-07-6
Molecular Formula:C₁₁H₁₀F₂O
Molecular Weight:196.197
Hs Code.:

Synonyms:methyl 2,2-difluoro-3-phenylcyclopropyl ketone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 2,2-difluoro-3-phenylcyclopropyl ketone

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methyl 2,2-difluoro-3-phenylcyclopropyl ketone

There total 5 articles about methyl 2,2-difluoro-3-phenylcyclopropyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1429215-47-3
methyl 2,2-difluoro-3-phenylcyclopropenyl ketone

: methyl 2,2-difluoro-3-phenylcyclopropyl ketone

: 82045-07-6
methyl 2,2-difluoro-3-phenylcyclopropyl ketone

Guidance literature:: With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; 3,5-di-tert-butylbenzoic acid; In toluene; at 20 ℃; for 96h; diastereoselective reaction;
DOI:10.1016/j.jfluchem.2013.02.003

Reference yield:

: 88493-26-9,88547-56-2
2,2-difluoro-1-(1-hydroxyethyl)-3-phenylcyclopropane

: 82045-07-6
methyl 2,2-difluoro-3-phenylcyclopropyl ketone

Guidance literature:: With jones reagent; In acetone; at 0 ℃; for 0.333333h; Yield given;
DOI:10.1021/jo00138a006

Reference yield:

: 82045-04-3
(rac)-(E)-2-acetoxy-4-phenylbut-3-ene

: 82045-07-6
methyl 2,2-difluoro-3-phenylcyclopropyl ketone

Guidance literature:: Multi-step reaction with 3 steps

1: bis-(2-methoxy-ethyl) ether / 0.33 h / Heating

2: KOH / methanol; tetrahydrofuran / 2 h / Ambient temperature

3: Jones reagent / acetone / 0.33 h / 0 °C

With potassium hydroxide; jones reagent; In tetrahydrofuran; methanol; diethylene glycol dimethyl ether; acetone;
DOI:10.1021/jo00138a006