3-{4-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-{3-[(methylsulfonyl)amino]propyl}phenyl)-4-oxoazetidin-2-yl]phenyl}-1,1-bis(hydroxymethyl)propyl acetate

Base Information

Chemical Name:3-{4-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-{3-[(methylsulfonyl)amino]propyl}phenyl)-4-oxoazetidin-2-yl]phenyl}-1,1-bis(hydroxymethyl)propyl acetate
CAS No.:1039433-08-3
Molecular Formula:C₃₇H₄₅FN₂O₉S
Molecular Weight:712.837
Hs Code.:

3-{4-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-{3-[(methylsulfonyl)amino]propyl}phenyl)-4-oxoazetidin-2-yl]phenyl}-1,1-bis(hydroxymethyl)propyl acetate

Synonyms:3-{4-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-{3-[(methylsulfonyl)amino]propyl}phenyl)-4-oxoazetidin-2-yl]phenyl}-1,1-bis(hydroxymethyl)propyl acetate

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Chemical Property of 3-{4-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-{3-[(methylsulfonyl)amino]propyl}phenyl)-4-oxoazetidin-2-yl]phenyl}-1,1-bis(hydroxymethyl)propyl acetate

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Technology Process of 3-{4-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-{3-[(methylsulfonyl)amino]propyl}phenyl)-4-oxoazetidin-2-yl]phenyl}-1,1-bis(hydroxymethyl)propyl acetate

There total 8 articles about 3-{4-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-{3-[(methylsulfonyl)amino]propyl}phenyl)-4-oxoazetidin-2-yl]phenyl}-1,1-bis(hydroxymethyl)propyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 932724-71-5
(1S)-3-[(2S,3R)-2-(4-{2-[5-(acetyloxy)-2.2-dimethyl-1,3-dioxan-5-yl]ethyl}phenyl)-1-(4-{3-[(methylsulfonyl)amino]propyl}phenyl)-4-oxoazetidin-3-yl]-1-(4-fluorophenyl)propyl acetate

: 1039433-08-3
3-{4-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-{3-[(methylsulfonyl)amino]propyl}phenyl)-4-oxoazetidin-2-yl]phenyl}-1,1-bis(hydroxymethyl)propyl acetate

Guidance literature:: With water; trifluoroacetic acid; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 917565-48-1
4-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-iodophenyl)-4-oxoazetidin-2-yl]phenyl acetate

: 1039433-08-3
3-{4-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-{3-[(methylsulfonyl)amino]propyl}phenyl)-4-oxoazetidin-2-yl]phenyl}-1,1-bis(hydroxymethyl)propyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: guanidine hydrochloride; triethylamine / methanol / 3 h

2.2: 2 h / 20 °C

3.1: copper(l) iodide; tetra-(n-butyl)ammonium iodide; triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 70 °C

4.1: hydrogen / palladium 10% on activated carbon; palladium(II) hydroxide/carbon / ethanol; ethyl acetate / 3 h

5.1: water; trifluoroacetic acid / tetrahydrofuran / 16 h / 20 °C

With copper(l) iodide; water; hydrogen; guanidine hydrochloride; tetra-(n-butyl)ammonium iodide; triethylamine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium(II) hydroxide/carbon; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 917565-59-4
(1S)-1-(4-fluorophenyl)-3-[(3R,4S)-1-(4-{3-[(methylsulfonyl)amino]propyl}phenyl)-2-oxo-4-(4-{[(trifluoromethyl)-sulfonyl]oxy}phenyl)azetidin-3-yl]propyl acetate

: 1039433-08-3
3-{4-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-{3-[(methylsulfonyl)amino]propyl}phenyl)-4-oxoazetidin-2-yl]phenyl}-1,1-bis(hydroxymethyl)propyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; tetra-(n-butyl)ammonium iodide; triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 70 °C

2: hydrogen / palladium 10% on activated carbon; palladium(II) hydroxide/carbon / ethanol; ethyl acetate / 3 h

3: water; trifluoroacetic acid / tetrahydrofuran / 16 h / 20 °C

With copper(l) iodide; water; hydrogen; tetra-(n-butyl)ammonium iodide; triethylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium(II) hydroxide/carbon; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide;