3-{[(1R)-1-{3-[(6-aminopyridin-3-yl)carbonyl]-4-chloro-2-fluorophenyl}propyl]amino}propanamide hydrochloride

Base Information

Chemical Name:3-{[(1R)-1-{3-[(6-aminopyridin-3-yl)carbonyl]-4-chloro-2-fluorophenyl}propyl]amino}propanamide hydrochloride
CAS No.:1433389-38-8
Molecular Formula:C₁₈H₂₀ClFN₄O₂*ClH
Molecular Weight:415.295
Hs Code.:

Synonyms:3-{[(1R)-1-{3-[(6-aminopyridin-3-yl)carbonyl]-4-chloro-2-fluorophenyl}propyl]amino}propanamide hydrochloride

Suppliers and Price of 3-{[(1R)-1-{3-[(6-aminopyridin-3-yl)carbonyl]-4-chloro-2-fluorophenyl}propyl]amino}propanamide hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-{[(1R)-1-{3-[(6-aminopyridin-3-yl)carbonyl]-4-chloro-2-fluorophenyl}propyl]amino}propanamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-{[(1R)-1-{3-[(6-aminopyridin-3-yl)carbonyl]-4-chloro-2-fluorophenyl}propyl]amino}propanamide hydrochloride

There total 9 articles about 3-{[(1R)-1-{3-[(6-aminopyridin-3-yl)carbonyl]-4-chloro-2-fluorophenyl}propyl]amino}propanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: [3-((R)-1-aminopropyl)-6-chloro-2-fluorophenyl]-(6-aminopyridin-3-yl)methanone hydrochloride

: 79-06-1,12624-24-7,25038-45-3,27754-57-0,33338-03-3,39387-77-4,68247-81-4,9082-06-8,79079-15-5
2-propenamide

: 1433389-38-8
3-{[(1R)-1-{3-[(6-aminopyridin-3-yl)carbonyl]-4-chloro-2-fluorophenyl}propyl]amino}propanamide hydrochloride

Guidance literature:: [3-((R)-1-aminopropyl)-6-chloro-2-fluorophenyl]-(6-aminopyridin-3-yl)methanone hydrochloride; With sodium hydroxide; In dichloromethane; water; pH=12;

2-propenamide; With manganese(II) chloride tetrahydrate; In ethanol; water; at 100 ℃; for 1.5h; Microwave irradiation;

With hydrogenchloride; In diethyl ether; dichloromethane;

Reference yield:

: 1433403-05-4
{(R)-1-[4-chloro-3-(6-chloropyridine-3-carbonyl)-2-fluorophenyl]propyl}carbamic acid tert-butyl ester

: 1433389-38-8
3-{[(1R)-1-{3-[(6-aminopyridin-3-yl)carbonyl]-4-chloro-2-fluorophenyl}propyl]amino}propanamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethyl sulfoxide / 50 °C

2.1: trifluoroacetic acid / dichloromethane / 20 - 70 °C

3.1: sodium hydroxide / dichloromethane; water / pH 12

3.2: 1.5 h / 100 °C / Microwave irradiation

With trifluoroacetic acid; sodium hydroxide; In dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 1433401-71-8
[(R)-1-(4-chloro-2-fluoro-phenyl)-propyl]-carbamic acid tert-butyl ester

: 1433389-38-8
3-{[(1R)-1-{3-[(6-aminopyridin-3-yl)carbonyl]-4-chloro-2-fluorophenyl}propyl]amino}propanamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C / Inert atmosphere

1.2: 0.5 h

2.1: dimethyl sulfoxide / 50 °C

3.1: trifluoroacetic acid / dichloromethane / 20 - 70 °C

4.1: sodium hydroxide / dichloromethane; water / pH 12

4.2: 1.5 h / 100 °C / Microwave irradiation

With n-butyllithium; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; hexane; dichloromethane; water; dimethyl sulfoxide;