1-(3-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenyl)propyl)guanidine

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Chemical Name:1-(3-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenyl)propyl)guanidine
CAS No.:1239957-11-9
Molecular Formula:C₃₀H₃₁ClF₃N₅OS
Molecular Weight:602.123
Hs Code.:

Synonyms:1-(3-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenyl)propyl)guanidine

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Chemical Property of 1-(3-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenyl)propyl)guanidine

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Technology Process of 1-(3-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenyl)propyl)guanidine

There total 12 articles about 1-(3-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenyl)propyl)guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1239963-53-1
tert-butyl (tert-butoxycarbonylamino)(3-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenyl)propylamino)methylenecarbamate

: 1239957-11-9
1-(3-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenyl)propyl)guanidine

Guidance literature:: tert-butyl (tert-butoxycarbonylamino)(3-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenyl)propylamino)methylenecarbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

With sodium hydrogencarbonate; In dichloromethane; water; ethyl acetate;

Reference yield:

: 850564-15-7
2-(4-Chloro-3-methoxy-phenyl)-2-methyl-propionitrile

: 1239957-11-9
1-(3-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenyl)propyl)guanidine

Guidance literature:: Multi-step reaction with 12 steps

1: sulfuric acid; water / 20 h / Reflux

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h

3: tetrahydrofuran / 2 h / -78 - 20 °C

4: tetra-N-butylammonium tribromide / methanol; dichloromethane / 3 h / 0 - 20 °C

5: sodium azide / N,N-dimethyl-formamide / 0 - 20 °C

6: hydrogenchloride; hydrogen / platinum(IV) oxide / methanol; water / 5 h / 2068.65 - 3361.55 Torr

7: acetic acid / 4 h / Reflux

8: potassium carbonate / acetone / 1 h

9: pyrrolidine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

10: hydrogen / platinum(IV) oxide / methanol / 36 h / 3361.55 Torr / Inert atmosphere

11: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran

12: trifluoroacetic acid / dichloromethane / 20 °C

With pyrrolidine; hydrogenchloride; dmap; sodium azide; di-isopropyl azodicarboxylate; sulfuric acid; water; hydrogen; tetra-N-butylammonium tribromide; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; trifluoroacetic acid; platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1239963-80-4
3-(4-chloro-3-methoxyphenyl)-3-methyl-2-methylbutan-2-one

: 1239957-11-9
1-(3-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenyl)propyl)guanidine

Guidance literature:: Multi-step reaction with 9 steps

1: tetra-N-butylammonium tribromide / methanol; dichloromethane / 3 h / 0 - 20 °C

2: sodium azide / N,N-dimethyl-formamide / 0 - 20 °C

3: hydrogenchloride; hydrogen / platinum(IV) oxide / methanol; water / 5 h / 2068.65 - 3361.55 Torr

4: acetic acid / 4 h / Reflux

5: potassium carbonate / acetone / 1 h

6: pyrrolidine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

7: hydrogen / platinum(IV) oxide / methanol / 36 h / 3361.55 Torr / Inert atmosphere

8: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran

9: trifluoroacetic acid / dichloromethane / 20 °C

With pyrrolidine; hydrogenchloride; sodium azide; di-isopropyl azodicarboxylate; hydrogen; tetra-N-butylammonium tribromide; potassium carbonate; acetic acid; triphenylphosphine; trifluoroacetic acid; platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;