ethyl 4-(3-[{tetrahydropyran-2-yl}-oxy]-propyl)-5-methyl-2-phenyl-1-phenylpyrrole-3-carboxylate

Base Information

• Chemical Name: ethyl 4-(3-[{tetrahydropyran-2-yl}-oxy]-propyl)-5-methyl-2-phenyl-1-phenylpyrrole-3-carboxylate
• CAS No.: 889454-89-1
• Molecular Formula: C₂₈H₃₃NO₄
• Molecular Weight: 447.574

Synonyms:ethyl 4-(3-[{tetrahydropyran-2-yl}-oxy]-propyl)-5-methyl-2-phenyl-1-phenylpyrrole-3-carboxylate

Chemical Property of ethyl 4-(3-[{tetrahydropyran-2-yl}-oxy]-propyl)-5-methyl-2-phenyl-1-phenylpyrrole-3-carboxylate

Chemical Property:

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Technology Process of ethyl 4-(3-[{tetrahydropyran-2-yl}-oxy]-propyl)-5-methyl-2-phenyl-1-phenylpyrrole-3-carboxylate

There total 2 articles about ethyl 4-(3-[{tetrahydropyran-2-yl}-oxy]-propyl)-5-methyl-2-phenyl-1-phenylpyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-benzoyl-3-[3-(tetrahydro-pyran-2-yloxy)-propyl]-penta-3,4-dienoic acid ethyl ester + aniline (62-53-3) → ethyl 4-(3-[{tetrahydropyran-2-yl}-oxy]-propyl)-5-methyl-2-phenyl-1-phenylpyrrole-3-carboxylate (889454-89-1)

Guidance literature:

With (triphenylphosphine)gold(I) chloride; In dichloromethane; at 38 ℃;

DOI:10.1021/ol060664z

Reference yield:

(E)-3-Phenyl-3-[6-(tetrahydro-pyran-2-yloxy)-hex-2-ynyloxy]-acrylic acid ethyl ester → ethyl 4-(3-[{tetrahydropyran-2-yl}-oxy]-propyl)-5-methyl-2-phenyl-1-phenylpyrrole-3-carboxylate (889454-89-1)

Guidance literature:

Multi-step reaction with 2 steps

1: AgSbF₆ / CH₂Cl₂ / 0.17 h / 20 °C

2: (Ph₃P)AuCl / CH₂Cl₂ / 38 °C

With silver hexafluoroantimonate; (triphenylphosphine)gold(I) chloride; In dichloromethane;

DOI:10.1021/ol060664z

Reference yield:

ethyl 4-(3-[{tetrahydropyran-2-yl}-oxy]-propyl)-5-methyl-2-phenyl-1-phenylpyrrole-3-carboxylate (889454-89-1) → 5-formyl-4-(3-oxo-propyl)-1,2-diphenyl-1H-pyrrole-3-carboxylic acid ethyl ester + 5-formyl-1,2-diphenyl-4-[3-(tetrahydro-pyran-2-yloxy)-propyl]-1H-pyrrole-3-carboxylic acid ethyl ester

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; at 110 ℃;

DOI:10.1021/ol060664z

upstream raw materials:

aniline

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