N-Benzyl-3-{2-[3-(2-benzylcarbamoyl-ethyl)-1H-indol-2-yldisulfanyl]-1H-indol-3-yl}-propionamide

Base Information

• Chemical Name: N-Benzyl-3-{2-[3-(2-benzylcarbamoyl-ethyl)-1H-indol-2-yldisulfanyl]-1H-indol-3-yl}-propionamide
• CAS No.: 153408-49-2
• Molecular Formula: C₃₆H₃₄N₄O₂S₂
• Molecular Weight: 618.824
• Mol file: 153408-49-2.mol

Synonyms:N-Benzyl-3-{2-[3-(2-benzylcarbamoyl-ethyl)-1H-indol-2-yldisulfanyl]-1H-indol-3-yl}-propionamide

Chemical Property of N-Benzyl-3-{2-[3-(2-benzylcarbamoyl-ethyl)-1H-indol-2-yldisulfanyl]-1H-indol-3-yl}-propionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Benzyl-3-{2-[3-(2-benzylcarbamoyl-ethyl)-1H-indol-2-yldisulfanyl]-1H-indol-3-yl}-propionamide

There total 4 articles about N-Benzyl-3-{2-[3-(2-benzylcarbamoyl-ethyl)-1H-indol-2-yldisulfanyl]-1H-indol-3-yl}-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Indole-3-propionic acid (830-96-6) → N-Benzyl-3-{2-[3-(2-benzylcarbamoyl-ethyl)-1H-indol-2-yldisulfanyl]-1H-indol-3-yl}-propionamide (153408-49-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / diethyl ether / 1 h / 20 °C

2: 88 percent / 4 h / 140 °C

3: 1.) S₂Cl₂, 2.) NaBH₄, 3.) aq. H₂O₂

With disulfur dichloride; sodium tetrahydroborate; dihydrogen peroxide; In diethyl ether;

DOI:10.1021/jm00031a009

Reference yield:

Methyl indole-3-propionate (5548-09-4) → N-Benzyl-3-{2-[3-(2-benzylcarbamoyl-ethyl)-1H-indol-2-yldisulfanyl]-1H-indol-3-yl}-propionamide (153408-49-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / 4 h / 140 °C

2: 1.) S₂Cl₂, 2.) NaBH₄, 3.) aq. H₂O₂

With disulfur dichloride; sodium tetrahydroborate; dihydrogen peroxide;

DOI:10.1021/jm00031a009

Reference yield:

benzylamine (100-46-9) → N-Benzyl-3-{2-[3-(2-benzylcarbamoyl-ethyl)-1H-indol-2-yldisulfanyl]-1H-indol-3-yl}-propionamide (153408-49-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / 4 h / 140 °C

2: 1.) S₂Cl₂, 2.) NaBH₄, 3.) aq. H₂O₂

With disulfur dichloride; sodium tetrahydroborate; dihydrogen peroxide;

DOI:10.1021/jm00031a009

upstream raw materials:

N-(phenylmethyl)-1H-indole-3-propanamide

Indole-3-propionic acid

Methyl indole-3-propionate

benzylamine