Aracytidine 5'-O-phenylphosphate

Base Information

Chemical Name:Aracytidine 5'-O-phenylphosphate
CAS No.:17489-61-1
Molecular Formula:C₁₅H₁₈N₃O₈P
Molecular Weight:399.297
Hs Code.:
NSC Number:128280
DSSTox Substance ID:DTXSID40938595
ChEMBL ID:CHEMBL1969245

Synonyms:17489-61-1;Aracytidine 5'-O-phenylphosphate;CHEMBL1969245;DTXSID40938595;NSC128280;NSC-128280;2(1H)-Pyrimidinone, 4-amino-1-[5-O-(hydroxyphenoxyphosphinyl)-.beta.-D-arabinofuranosyl]-;Cytosinearabinoside 5'-O-phenylphosphate;Cytosine, 5'-(phenyl hydrogen phosphate);NCI60_000643;1-{5-O-[Hydroxy(phenoxy)phosphoryl]pentofuranosyl}-4-imino-1,4-dihydropyrimidin-2-ol

Suppliers and Price of Aracytidine 5'-O-phenylphosphate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Aracytidine 5'-O-phenylphosphate

Chemical Property:

Vapor Pressure:2.71E-18mmHg at 25°C
Boiling Point:659.5°C at 760 mmHg
Flash Point:352.7°C
Density:1.75g/cm³
XLogP3:-1.1
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:6
Exact Mass:399.08315154
Heavy Atom Count:27
Complexity:665

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)OP(=O)(O)OCC2C(C(C(O2)N3C=CC(=NC3=O)N)O)O

Technology Process of Aracytidine 5'-O-phenylphosphate

There total 5 articles about Aracytidine 5'-O-phenylphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Butyric acid (2R,3S,4R,5R)-2-(4-butyrylamino-2-oxo-2H-pyrimidin-1-yl)-4-butyryloxy-5-(hydroxy-phenoxy-phosphoryloxymethyl)-tetrahydro-furan-3-yl ester

: 17489-61-1
4-amino-1-[O⁵-(hydroxy-phenoxy-phosphoryl)-β-D-arabinofuranosyl]-1H-pyrimidin-2-one

Guidance literature:: With ammonia; In ethanol; Yield given;
DOI:10.1248/cpb.28.2915

Reference yield:

: 34349-17-2
1-β-D-arabinofuranosylcytosine 3',5'-diphosphate

: 17489-61-1
4-amino-1-[O⁵-(hydroxy-phenoxy-phosphoryl)-β-D-arabinofuranosyl]-1H-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 5 g / nuclease-3'-nucleotidase P₁, CH₃COONa, / H₂O / 24 h / 60 °C

2: 1.) tri-n-butylamine 2.) H₂) / 1.) pyridine, RT, 20 h, 2.) RT, 20 h,

3: 1.) TPS-Cl, / 1.) CHCl₃, 2.) pyridine, RT, 5 h,

4: NH₃ / ethanol

With tributyl-amine; Triphenylsilyl chloride; nuclease-3'-nucleotidase P₁; ammonia; hydrogen; sodium acetate; In ethanol; water;
DOI:10.1248/cpb.28.2915

Reference yield:

: 65139-86-8
N₄,2',3'-tri-n-butyryl Ara CMP

: 17489-61-1
4-amino-1-[O⁵-(hydroxy-phenoxy-phosphoryl)-β-D-arabinofuranosyl]-1H-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) TPS-Cl, / 1.) CHCl₃, 2.) pyridine, RT, 5 h,

2: NH₃ / ethanol

With Triphenylsilyl chloride; ammonia; In ethanol;
DOI:10.1248/cpb.28.2915