tert-Butyl-((4R,7R)-7-methyl-7-vinyl-4,5,6,7-tetrahydro-isobenzofuran-4-yloxy)-diphenyl-silane

Base Information

Chemical Name:tert-Butyl-((4R,7R)-7-methyl-7-vinyl-4,5,6,7-tetrahydro-isobenzofuran-4-yloxy)-diphenyl-silane
CAS No.:862847-02-7
Molecular Formula:C₂₇H₃₂O₂Si
Molecular Weight:416.635
Hs Code.:

Synonyms:tert-Butyl-((4R,7R)-7-methyl-7-vinyl-4,5,6,7-tetrahydro-isobenzofuran-4-yloxy)-diphenyl-silane

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Chemical Property of tert-Butyl-((4R,7R)-7-methyl-7-vinyl-4,5,6,7-tetrahydro-isobenzofuran-4-yloxy)-diphenyl-silane

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Technology Process of tert-Butyl-((4R,7R)-7-methyl-7-vinyl-4,5,6,7-tetrahydro-isobenzofuran-4-yloxy)-diphenyl-silane

There total 5 articles about tert-Butyl-((4R,7R)-7-methyl-7-vinyl-4,5,6,7-tetrahydro-isobenzofuran-4-yloxy)-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 862846-96-6
(4R,7R)-7-Methyl-7-vinyl-4,5,6,7-tetrahydro-isobenzofuran-4-ol

: 58479-61-1
tert-butylchlorodiphenylsilane

: 862847-02-7
tert-Butyl-((4R,7R)-7-methyl-7-vinyl-4,5,6,7-tetrahydro-isobenzofuran-4-yloxy)-diphenyl-silane

Guidance literature:: With 1H-imidazole; dmap; In dichloromethane; at 0 ℃;
DOI:10.1021/ol047387l

Reference yield:

: 441004-47-3
(E)-1-(4-Iodo-furan-3-yl)-4-methyl-hex-4-en-1-one

: 862847-02-7
tert-Butyl-((4R,7R)-7-methyl-7-vinyl-4,5,6,7-tetrahydro-isobenzofuran-4-yloxy)-diphenyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1: (+)-B-chlorodiisopinocamphenylborane / tetrahydrofuran / -20 °C

2: triethylamine; tetra-n-butylammonium bromide / palladium(II) acetate / acetonitrile; H₂O

3: 98 percent / imidazole; 4-N,N-(dimethylamino)pyridine / CH₂Cl₂ / 0 °C

With 1H-imidazole; dmap; tetrabutylammomium bromide; triethylamine; B-chlorodiisopinocampheylborane; palladium diacetate; In tetrahydrofuran; dichloromethane; water; acetonitrile; 2: Heck cyclization;
DOI:10.1021/ja0660507

Reference yield:

: 627075-78-9
(E)-1-(4-Iodo-furan-3-yl)-4-methyl-hex-4-en-1-ol

: 862847-02-7
tert-Butyl-((4R,7R)-7-methyl-7-vinyl-4,5,6,7-tetrahydro-isobenzofuran-4-yloxy)-diphenyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / Dess-Martin periodinane / CH₂Cl₂ / 20 °C

2: (+)-B-chlorodiisopinocamphenylborane / tetrahydrofuran / -20 °C

3: triethylamine; tetra-n-butylammonium bromide / palladium(II) acetate / acetonitrile; H₂O

4: 98 percent / imidazole; 4-N,N-(dimethylamino)pyridine / CH₂Cl₂ / 0 °C

With 1H-imidazole; dmap; tetrabutylammomium bromide; Dess-Martin periodane; triethylamine; B-chlorodiisopinocampheylborane; palladium diacetate; In tetrahydrofuran; dichloromethane; water; acetonitrile; 3: Heck cyclization;
DOI:10.1021/ja0660507