7-[4-(3-amino-oxetan-3-yl)-phenyl]-8-phenyl-2H-9-oxa-1,2,3a-triaza-cyclopenta[a]naphthalene-3,6-dione

Base Information

Chemical Name:7-[4-(3-amino-oxetan-3-yl)-phenyl]-8-phenyl-2H-9-oxa-1,2,3a-triaza-cyclopenta[a]naphthalene-3,6-dione
CAS No.:1279086-26-8
Molecular Formula:C₂₄H₁₈N₄O₄
Molecular Weight:426.431
Hs Code.:

Synonyms:7-[4-(3-amino-oxetan-3-yl)-phenyl]-8-phenyl-2H-9-oxa-1,2,3a-triaza-cyclopenta[a]naphthalene-3,6-dione

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Chemical Property of 7-[4-(3-amino-oxetan-3-yl)-phenyl]-8-phenyl-2H-9-oxa-1,2,3a-triaza-cyclopenta[a]naphthalene-3,6-dione

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Technology Process of 7-[4-(3-amino-oxetan-3-yl)-phenyl]-8-phenyl-2H-9-oxa-1,2,3a-triaza-cyclopenta[a]naphthalene-3,6-dione

There total 3 articles about 7-[4-(3-amino-oxetan-3-yl)-phenyl]-8-phenyl-2H-9-oxa-1,2,3a-triaza-cyclopenta[a]naphthalene-3,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1279089-28-9
2-methyl-propane-2-sulfinic acid (3-{4-[3,6-dioxo-8-phenyl-2-(2-trimethylsilanyl-ethoxymethyl)-2,6-dihydro-3H-9-oxa-1,2,3a-triaza-cyclopenta[a]naphthalen-7-yl]-phenyl}-oxetan-3-yl)-amide

: 1279086-26-8
7-[4-(3-amino-oxetan-3-yl)-phenyl]-8-phenyl-2H-9-oxa-1,2,3a-triaza-cyclopenta[a]naphthalene-3,6-dione

Guidance literature:: 2-methyl-propane-2-sulfinic acid (3-{4-[3,6-dioxo-8-phenyl-2-(2-trimethylsilanyl-ethoxymethyl)-2,6-dihydro-3H-9-oxa-1,2,3a-triaza-cyclopenta[a]naphthalen-7-yl]-phenyl}-oxetan-3-yl)-amide; With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 1h;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h; Cooling;

With ammonia; In methanol;

Reference yield:

: 1279089-24-5
2-methyl-propane-2-sulfinic acid {3-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-phenyl]-oxetan-3-yl}-amide

: 1279086-26-8
7-[4-(3-amino-oxetan-3-yl)-phenyl]-8-phenyl-2H-9-oxa-1,2,3a-triaza-cyclopenta[a]naphthalene-3,6-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 1 h / 125 °C / Inert atmosphere; microwave reactor

2.1: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 20 °C

2.2: 1 h / 20 °C / Cooling

With hydrogenchloride; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; water;

Reference yield:

: 1279089-26-7
(±)-N-[3-(4-bromophenyl)oxetan-3-yl]-2-methyl-propane-2-sulfinamide

: 1279086-26-8
7-[4-(3-amino-oxetan-3-yl)-phenyl]-8-phenyl-2H-9-oxa-1,2,3a-triaza-cyclopenta[a]naphthalene-3,6-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 18 h / 85 °C / Inert atmosphere

2.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 1 h / 125 °C / Inert atmosphere; microwave reactor

3.1: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 20 °C

3.2: 1 h / 20 °C / Cooling

With hydrogenchloride; potassium acetate; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; dimethyl sulfoxide;