1,1-dimethylethyl *,S^*-(E)>>-7-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3,5-dihydroxy-6-heptenoate

Base Information

• Chemical Name: 1,1-dimethylethyl *,S^*-(E)>>-7-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3,5-dihydroxy-6-heptenoate
• CAS No.: 141046-44-8
• Molecular Formula: C₂₈H₃₄FN₃O₄
• Molecular Weight: 495.594

Synonyms:1,1-dimethylethyl *,S^*-(E)>>-7-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3,5-dihydroxy-6-heptenoate

Chemical Property of 1,1-dimethylethyl *,S^*-(E)>>-7-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3,5-dihydroxy-6-heptenoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1-dimethylethyl *,S^*-(E)>>-7-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3,5-dihydroxy-6-heptenoate

There total 12 articles about 1,1-dimethylethyl *,S^*-(E)>>-7-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3,5-dihydroxy-6-heptenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pyrid-2-ylhydrazine (4930-98-7) → 1,1-dimethylethyl *,S*-(E)>>-7-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3,5-dihydroxy-6-heptenoate (141046-44-8)

Guidance literature:

Multi-step reaction with 8 steps

1: 64 percent / acetic acid / 3 h / 60 °C

2: 50 percent / phosphorus oxychloride / 48 h / 70 °C

3: 1.) sodium hydride / 1.) THF, 0 deg C, 10 min, 2.) THF, -78 deg C - RT, 1 h

4: 66 percent / Raney nickel / formic acid / 60 °C

5: 1.) lithium diisopropylamide, 2.) MgBr₂

6: 81 percent / methanol / 16 h

7: 1.) lithium diisopropylamide / 1.) hexane, THF, -45 deg C, 1 h, 2.) hexane, THF, -45 deg C - -20 deg C, 3.5 h

8: 1.) triethylborane, pivalic acid, 2.) sodium borohydride / 1.) THF, methanol, 30 min, 2.) THF, methanol, -78 deg C, 6 h

With sodium tetrahydroborate; triethyl borane; sodium hydride; magnesium bromide; lithium diisopropyl amide; trichlorophosphate; Trimethylacetic acid; nickel; In methanol; formic acid; acetic acid;

DOI:10.1021/jm00089a022

Reference yield:

1-(4-Fluorophenyl)-3-isopropylpropan-1,3-dione (114433-94-2) → 1,1-dimethylethyl *,S*-(E)>>-7-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3,5-dihydroxy-6-heptenoate (141046-44-8)

Guidance literature:

Multi-step reaction with 8 steps

1: 64 percent / acetic acid / 3 h / 60 °C

2: 50 percent / phosphorus oxychloride / 48 h / 70 °C

3: 1.) sodium hydride / 1.) THF, 0 deg C, 10 min, 2.) THF, -78 deg C - RT, 1 h

4: 66 percent / Raney nickel / formic acid / 60 °C

5: 1.) lithium diisopropylamide, 2.) MgBr₂

6: 81 percent / methanol / 16 h

7: 1.) lithium diisopropylamide / 1.) hexane, THF, -45 deg C, 1 h, 2.) hexane, THF, -45 deg C - -20 deg C, 3.5 h

8: 1.) triethylborane, pivalic acid, 2.) sodium borohydride / 1.) THF, methanol, 30 min, 2.) THF, methanol, -78 deg C, 6 h

With sodium tetrahydroborate; triethyl borane; sodium hydride; magnesium bromide; lithium diisopropyl amide; trichlorophosphate; Trimethylacetic acid; nickel; In methanol; formic acid; acetic acid;

DOI:10.1021/jm00089a022

Reference yield:

2-[5-(4-fluorophenyl)-3-(1-methylethyl)-1H-pyrazol-1-yl]pyridine (114433-95-3) → 1,1-dimethylethyl *,S*-(E)>>-7-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3,5-dihydroxy-6-heptenoate (141046-44-8)

Guidance literature:

Multi-step reaction with 7 steps

1: 50 percent / phosphorus oxychloride / 48 h / 70 °C

2: 1.) sodium hydride / 1.) THF, 0 deg C, 10 min, 2.) THF, -78 deg C - RT, 1 h

3: 66 percent / Raney nickel / formic acid / 60 °C

4: 1.) lithium diisopropylamide, 2.) MgBr₂

5: 81 percent / methanol / 16 h

6: 1.) lithium diisopropylamide / 1.) hexane, THF, -45 deg C, 1 h, 2.) hexane, THF, -45 deg C - -20 deg C, 3.5 h

7: 1.) triethylborane, pivalic acid, 2.) sodium borohydride / 1.) THF, methanol, 30 min, 2.) THF, methanol, -78 deg C, 6 h

With sodium tetrahydroborate; triethyl borane; sodium hydride; magnesium bromide; lithium diisopropyl amide; trichlorophosphate; Trimethylacetic acid; nickel; In methanol; formic acid;

DOI:10.1021/jm00089a022

upstream raw materials:

1,1-dimethylethyl -7-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-5-hydroxy-3-oxo-6-heptenoate

pyrid-2-ylhydrazine

1-(4-Fluorophenyl)-3-isopropylpropan-1,3-dione

2-[5-(4-fluorophenyl)-3-(1-methylethyl)-1H-pyrazol-1-yl]pyridine

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