3-(p-benzyloxyphenyl)-3-(tert-butoxycarbonylamino)-2,2-difluoropropionic acid

Base Information

Chemical Name:3-(p-benzyloxyphenyl)-3-(tert-butoxycarbonylamino)-2,2-difluoropropionic acid
CAS No.:171252-07-6
Molecular Formula:C₂₁H₂₃F₂NO₅
Molecular Weight:407.414
Hs Code.:

Synonyms:3-(p-benzyloxyphenyl)-3-(tert-butoxycarbonylamino)-2,2-difluoropropionic acid

Suppliers and Price of 3-(p-benzyloxyphenyl)-3-(tert-butoxycarbonylamino)-2,2-difluoropropionic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(p-benzyloxyphenyl)-3-(tert-butoxycarbonylamino)-2,2-difluoropropionic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(p-benzyloxyphenyl)-3-(tert-butoxycarbonylamino)-2,2-difluoropropionic acid

There total 6 articles about 3-(p-benzyloxyphenyl)-3-(tert-butoxycarbonylamino)-2,2-difluoropropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 171252-06-5
3-(4-Benzyloxy-phenyl)-3-tert-butoxycarbonylamino-2,2-difluoro-propionic acid ethyl ester

: 171252-07-6
3-(p-benzyloxyphenyl)-3-(tert-butoxycarbonylamino)-2,2-difluoropropionic acid

Guidance literature:: With lithium hydroxide; In ethanol; water; for 0.5h; Ambient temperature;
DOI:10.1248/cpb.45.1793

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 171252-07-6
3-(p-benzyloxyphenyl)-3-(tert-butoxycarbonylamino)-2,2-difluoropropionic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 87 percent / zinc / tetrahydrofuran / 0.25 h / Heating

2: Et₃N / CH₂Cl₂ / 5.1 h

3: n-Bu₄NBr, NaN₃ / dimethylformamide / 40 h / 65 °C

4: H₂ / Lindlar catalyst / ethanol / 6 h / Ambient temperature

5: NaHCO₃ / tetrahydrofuran / 17 h / 60 °C

6: 89 percent / LiOH / ethanol; H₂O / 0.5 h / Ambient temperature

With lithium hydroxide; sodium azide; tetrabutylammomium bromide; hydrogen; sodium hydrogencarbonate; triethylamine; zinc; Lindlar's catalyst; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.45.1793

Reference yield:

: 200501-08-2
3-(4-Benzyloxy-phenyl)-2,2-difluoro-3-hydroxy-propionic acid ethyl ester

: 171252-07-6
3-(p-benzyloxyphenyl)-3-(tert-butoxycarbonylamino)-2,2-difluoropropionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / CH₂Cl₂ / 5.1 h

2: n-Bu₄NBr, NaN₃ / dimethylformamide / 40 h / 65 °C

3: H₂ / Lindlar catalyst / ethanol / 6 h / Ambient temperature

4: NaHCO₃ / tetrahydrofuran / 17 h / 60 °C

5: 89 percent / LiOH / ethanol; H₂O / 0.5 h / Ambient temperature

With lithium hydroxide; sodium azide; tetrabutylammomium bromide; hydrogen; sodium hydrogencarbonate; triethylamine; Lindlar's catalyst; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.45.1793