(E)-(6-fluoro-2,3-dihydro-4H-chromen-4-ylidene)methyl 4-bromobenzenesulfonate

Base Information

Chemical Name:(E)-(6-fluoro-2,3-dihydro-4H-chromen-4-ylidene)methyl 4-bromobenzenesulfonate
CAS No.:1622092-81-2
Molecular Formula:C₁₆H₁₂BrFO₄S
Molecular Weight:399.237
Hs Code.:

Synonyms:(E)-(6-fluoro-2,3-dihydro-4H-chromen-4-ylidene)methyl 4-bromobenzenesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-(6-fluoro-2,3-dihydro-4H-chromen-4-ylidene)methyl 4-bromobenzenesulfonate

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Technology Process of (E)-(6-fluoro-2,3-dihydro-4H-chromen-4-ylidene)methyl 4-bromobenzenesulfonate

There total 3 articles about (E)-(6-fluoro-2,3-dihydro-4H-chromen-4-ylidene)methyl 4-bromobenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1622092-53-8
2-(2-ethynyl-4-fluorophenoxy)ethyl 4-bromobenzenesulfonate

: 1622092-81-2
(E)-(6-fluoro-2,3-dihydro-4H-chromen-4-ylidene)methyl 4-bromobenzenesulfonate

Guidance literature:: With {1-cyclopentadecyl-3-[2,6-di(propan-2-yl)phenyl]-1,3-dihydro-2H-imidazol-2-ylidene}(prop-1-yn-1-yl)gold; In benzene; at 90 ℃; for 48h; Sealed tube;
DOI:10.1002/anie.201310280

Reference yield:

: 98-58-8
4-bromobenzenesulfonyl chloride

: 1622092-81-2
(E)-(6-fluoro-2,3-dihydro-4H-chromen-4-ylidene)methyl 4-bromobenzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; pyridine / dichloromethane / 5 h / 0 - 20 °C

2: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 19 h / 0 - 20 °C / Inert atmosphere

3: {1-cyclopentadecyl-3-[2,6-di(propan-2-yl)phenyl]-1,3-dihydro-2H-imidazol-2-ylidene}(prop-1-yn-1-yl)gold / benzene / 48 h / 90 °C / Sealed tube

With pyridine; dmap; {1-cyclopentadecyl-3-[2,6-di(propan-2-yl)phenyl]-1,3-dihydro-2H-imidazol-2-ylidene}(prop-1-yn-1-yl)gold; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; benzene; 2: |Mitsunobu Displacement;
DOI:10.1002/anie.201310280

Reference yield:

: 89980-99-4
2-hydroxyethyl 4-bromobenzenesulfonate

: 1622092-81-2
(E)-(6-fluoro-2,3-dihydro-4H-chromen-4-ylidene)methyl 4-bromobenzenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 19 h / 0 - 20 °C / Inert atmosphere

2: {1-cyclopentadecyl-3-[2,6-di(propan-2-yl)phenyl]-1,3-dihydro-2H-imidazol-2-ylidene}(prop-1-yn-1-yl)gold / benzene / 48 h / 90 °C / Sealed tube

With {1-cyclopentadecyl-3-[2,6-di(propan-2-yl)phenyl]-1,3-dihydro-2H-imidazol-2-ylidene}(prop-1-yn-1-yl)gold; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; benzene; 1: |Mitsunobu Displacement;
DOI:10.1002/anie.201310280