bis-[2-(toluene-4-sulfonylamino)-ethyl]-phosphoramidic acid diethyl ester

Base Information

• Chemical Name: bis-[2-(toluene-4-sulfonylamino)-ethyl]-phosphoramidic acid diethyl ester
• CAS No.: 247211-07-0
• Molecular Formula: C₂₂H₃₄N₃O₇PS₂
• Molecular Weight: 547.634

Synonyms:bis-[2-(toluene-4-sulfonylamino)-ethyl]-phosphoramidic acid diethyl ester

Chemical Property of bis-[2-(toluene-4-sulfonylamino)-ethyl]-phosphoramidic acid diethyl ester

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Technology Process of bis-[2-(toluene-4-sulfonylamino)-ethyl]-phosphoramidic acid diethyl ester

There total 3 articles about bis-[2-(toluene-4-sulfonylamino)-ethyl]-phosphoramidic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(diethoxyphosphoryl)-O,O'-bis(2-methylsulfonyl)di-ethanolamine (166303-07-7) → bis-[2-(toluene-4-sulfonylamino)-ethyl]-phosphoramidic acid diethyl ester (247211-07-0)

Guidance literature:

Multi-step reaction with 3 steps

1: NaN₃ / dimethylformamide / 18 h / 80 °C

2: H₂ / Pd/C / ethyl acetate

3: Et₃N / CH₂Cl₂

With sodium azide; hydrogen; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 1: Substitution / 2: Hydrogenation / 3: Tosylation;

DOI:10.1021/jm990211i

Reference yield:

bis-(2-azido-ethyl)-phosphoramidic acid diethyl ester → bis-[2-(toluene-4-sulfonylamino)-ethyl]-phosphoramidic acid diethyl ester (247211-07-0)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / ethyl acetate

2: Et₃N / CH₂Cl₂

With hydrogen; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate; 1: Hydrogenation / 2: Tosylation;

DOI:10.1021/jm990211i

Reference yield:

p-toluenesulfonyl chloride (98-59-9) + bis-(2-amino-ethyl)-phosphoramidic acid diethyl ester (685495-44-7) → bis-[2-(toluene-4-sulfonylamino)-ethyl]-phosphoramidic acid diethyl ester (247211-07-0)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1021/jm990211i

upstream raw materials:

p-toluenesulfonyl chloride

bis-(2-amino-ethyl)-phosphoramidic acid diethyl ester

N-(diethoxyphosphoryl)-O,O'-bis(2-methylsulfonyl)di-ethanolamine

Downstream raw materials:

3,9-bis(p-toluenesulfonyl)-3,6,9,15-tetraazabicyclo[11.3.1]pentadeca-1⁽¹⁵⁾,11,13-triene

C₅₈H₆₆N₈O₈S₄

C₅₈H₆₆N₈O₈S₄

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