(2S)-neopentyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-ethoxy-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(2-chlorophenoxy)phosphoryl)amino)propanoate

Base Information

Chemical Name:(2S)-neopentyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-ethoxy-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(2-chlorophenoxy)phosphoryl)amino)propanoate
CAS No.:1615696-42-8
Molecular Formula:C₂₇H₃₇ClFN₆O₈P
Molecular Weight:659.051
Hs Code.:

(2S)-neopentyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-ethoxy-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(2-chlorophenoxy)phosphoryl)amino)propanoate

Synonyms:(2S)-neopentyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-ethoxy-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(2-chlorophenoxy)phosphoryl)amino)propanoate

Suppliers and Price of (2S)-neopentyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-ethoxy-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(2-chlorophenoxy)phosphoryl)amino)propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S)-neopentyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-ethoxy-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(2-chlorophenoxy)phosphoryl)amino)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S)-neopentyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-ethoxy-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(2-chlorophenoxy)phosphoryl)amino)propanoate

There total 9 articles about (2S)-neopentyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-ethoxy-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(2-chlorophenoxy)phosphoryl)amino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1434144-31-6
(2R,3S,4R,5R)-2-(2-amino-6-ethoxy-9H-purin-9-yl)-4-fluoro-5-(hydroxymethyl)-3-methyltetrahydrofuran-3-ol

: 1426311-73-0
C₁₄H₂₀Cl₂NO₄P

: 1615696-42-8
(2S)-neopentyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-ethoxy-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(2-chlorophenoxy)phosphoryl)amino)propanoate

Guidance literature:: (2R,3S,4R,5R)-2-(2-amino-6-ethoxy-9H-purin-9-yl)-4-fluoro-5-(hydroxymethyl)-3-methyltetrahydrofuran-3-ol; With tert-butylmagnesium chloride; In tetrahydrofuran; at -78 - 20 ℃; for 0.5h;

C₁₄H₂₀Cl₂NO₄P; at -78 - 20 ℃; for 2h;

Reference yield:

: 1615696-39-3
C₂₁H₂₃FO₅

: 1615696-42-8
(2S)-neopentyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-ethoxy-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(2-chlorophenoxy)phosphoryl)amino)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / acetic acid / 12 h / 0 - 20 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.5 h / 0 - 20 °C / Inert atmosphere

2.2: 4 h / 0 - 60 °C

3.1: ethanol / 16 h / 20 °C

3.2: pH 7

4.1: tert-butylmagnesium chloride / tetrahydrofuran / 0.5 h / -78 - 20 °C

4.2: 2 h / -78 - 20 °C

With sulfuric acid; tert-butylmagnesium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; ethanol; acetic acid; acetonitrile;

Reference yield:

: methyl 5-O-benzyl-3-deoxy-3-fluoro-α-D-ribofuranoside

: 1615696-42-8
(2S)-neopentyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-ethoxy-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(2-chlorophenoxy)phosphoryl)amino)propanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 12 h / 80 °C

2.1: tetrahydrofuran / 12 h / -78 - 20 °C / Inert atmosphere

3.1: dmap; triethylamine / dichloromethane / 12 h / 20 °C / Cooling with ice

4.1: sulfuric acid / acetic acid / 12 h / 0 - 20 °C

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.5 h / 0 - 20 °C / Inert atmosphere

5.2: 4 h / 0 - 60 °C

6.1: ethanol / 16 h / 20 °C

6.2: pH 7

7.1: tert-butylmagnesium chloride / tetrahydrofuran / 0.5 h / -78 - 20 °C

7.2: 2 h / -78 - 20 °C

With dmap; sulfuric acid; tert-butylmagnesium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; ethanol; dichloromethane; acetic acid; acetonitrile;