4-Pentenamide, N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-2-(1-methylethyl)-, (2S)-

Base Information

Chemical Name:4-Pentenamide, N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-2-(1-methylethyl)-, (2S)-
CAS No.:324763-40-8
Molecular Formula:C₁₈H₂₇NO₂
Molecular Weight:289.418
Hs Code.:
DSSTox Substance ID:DTXSID401122063
Nikkaji Number:J1.450.756F

Synonyms:324763-40-8;4-Pentenamide, N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-2-(1-methylethyl)-, (2S)-;(2S)-N-[(1S,2S)-1-hydroxy-1-phenylpropan-2-yl]-N-methyl-2-(propan-2-yl)pent-4-enamide;DTXSID401122063;(2S)-N-[(1S,2S)-2-Hydroxy-1-methyl-2-phenylethyl]-N-methyl-2-(1-methylethyl)-4-pentenamide

Suppliers and Price of 4-Pentenamide, N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-2-(1-methylethyl)-, (2S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 4-Pentenamide, N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-2-(1-methylethyl)-, (2S)-

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:7
Exact Mass:289.204179104
Heavy Atom Count:21
Complexity:334

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)C(CC=C)C(=O)N(C)C(C)C(C1=CC=CC=C1)O
Isomeric SMILES:C[C@@H]([C@H](C1=CC=CC=C1)O)N(C)C(=O)[C@@H](CC=C)C(C)C

Technology Process of 4-Pentenamide, N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-2-(1-methylethyl)-, (2S)-

There total 1 articles about 4-Pentenamide, N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-2-(1-methylethyl)-, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 106-95-6
allyl bromide

: 192060-34-7
N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-3-N-dimethylbutyramide

: (R)-2-Isopropyl-pent-4-enoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

: 324763-40-8
(S)-2-Isopropyl-pent-4-enoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

Guidance literature:: N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-3-N-dimethylbutyramide; With lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; at 0 ℃;

allyl bromide; at 0 ℃;
DOI:10.1016/S0040-4039(00)01760-3

Reference yield: 60.0%

: 324763-40-8
(S)-2-Isopropyl-pent-4-enoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

(2S,3S,5R,7S,9S)-7-Bromomethyl-9-isopropyl-3,4-dimethyl-2-phenyl-1,6-dioxa-4-aza-spiro[4.4]nonane: 324763-41-9
(2S,3S,5R,7S,9S)-7-Bromomethyl-9-isopropyl-3,4-dimethyl-2-phenyl-1,6-dioxa-4-aza-spiro[4.4]nonane

Guidance literature:: With N-Bromosuccinimide; In 1,2-dimethoxyethane; water; at 0 ℃;
DOI:10.1016/S0040-4039(00)01760-3

Reference yield:

: 324763-40-8
(S)-2-Isopropyl-pent-4-enoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

: 324763-47-5
(2S,4S,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 60 percent / NBS / 1,2-dimethoxy-ethane; H₂O / 0 °C

2.1: n-Bu₄NOAc / acetone / Heating

2.2: 85 percent / K₂CO₃ / methanol; H₂O / 20 °C

3.1: 60 percent / Py*SO₃; Et₃N / dimethylsulfoxide; CH₂Cl₂ / 0 °C

4.1: 51 percent

5.1: DMAP / CH₂Cl₂ / 20 °C

6.1: NaN₃; NMP / 60 °C

7.1: 76 percent / 2-hydroxypyridine; Et₃N / 80 °C

With 2-hydroxypyridin; 1-methyl-pyrrolidin-2-one; dmap; N-Bromosuccinimide; sodium azide; tetrabutylammonium acetate; sulfur trioxide pyridine complex; triethylamine; In 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; acetone;
DOI:10.1016/S0040-4039(00)01760-3