2-((Z)-2-(2-fluorostyryl)-5-nitro-1H-imidazol-1-yl)ethyl 2,3-dihydro-1,4-benzodioxine-5-carboxylate

Base Information

• Chemical Name: 2-((Z)-2-(2-fluorostyryl)-5-nitro-1H-imidazol-1-yl)ethyl 2,3-dihydro-1,4-benzodioxine-5-carboxylate
• CAS No.: 1609584-09-9
• Molecular Formula: C₂₂H₁₈FN₃O₆
• Molecular Weight: 439.4
• Mol file: 1609584-09-9.mol

Synonyms:2-((Z)-2-(2-fluorostyryl)-5-nitro-1H-imidazol-1-yl)ethyl 2,3-dihydro-1,4-benzodioxine-5-carboxylate

Chemical Property of 2-((Z)-2-(2-fluorostyryl)-5-nitro-1H-imidazol-1-yl)ethyl 2,3-dihydro-1,4-benzodioxine-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((Z)-2-(2-fluorostyryl)-5-nitro-1H-imidazol-1-yl)ethyl 2,3-dihydro-1,4-benzodioxine-5-carboxylate

There total 10 articles about 2-((Z)-2-(2-fluorostyryl)-5-nitro-1H-imidazol-1-yl)ethyl 2,3-dihydro-1,4-benzodioxine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H15N3O6 (1609584-70-4) + 2-Fluorobenzaldehyde (446-52-6) → 2-((Z)-2-(2-fluorostyryl)-5-nitro-1H-imidazol-1-yl)ethyl 2,3-dihydro-1,4-benzodioxine-5-carboxylate (1609584-09-9)

Guidance literature:

With sodium hydroxide; In methanol; dimethyl sulfoxide; at 20 ℃;

DOI:10.1016/j.bmc.2014.04.005

Reference yield:

2,3-dihydro-1,4-benzodioxine-5-carboxylic acid (4442-53-9) + C20H18FN3O5S (1609584-58-8) → 2-((Z)-2-(2-fluorostyryl)-5-nitro-1H-imidazol-1-yl)ethyl 2,3-dihydro-1,4-benzodioxine-5-carboxylate (1609584-09-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2014.04.005

Reference yield:

methyl-2,3-dihydroxybenzoate (2411-83-8) → 2-((Z)-2-(2-fluorostyryl)-5-nitro-1H-imidazol-1-yl)ethyl 2,3-dihydro-1,4-benzodioxine-5-carboxylate (1609584-09-9)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 70 °C / Inert atmosphere

2: methanol; sodium hydroxide / water; tetrahydrofuran / 2 h / 75 °C

3: potassium carbonate / N,N-dimethyl-formamide

With methanol; potassium carbonate; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.bmc.2014.04.005

upstream raw materials:

2-Fluorobenzaldehyde

C₁₅H₁₅N₃O₆

2,3-dihydro-1,4-benzodioxine-5-carboxylic acid

C₂₀H₁₈FN₃O₅S