3-(tert-Butyl-dimethyl-silanyloxy)-6-hydroxy-2,2,6-trimethyl-cyclohexanecarbaldehyde

Base Information

Chemical Name:3-(tert-Butyl-dimethyl-silanyloxy)-6-hydroxy-2,2,6-trimethyl-cyclohexanecarbaldehyde
CAS No.:209069-54-5
Molecular Formula:C₁₆H₃₂O₃Si
Molecular Weight:300.514
Hs Code.:

Synonyms:3-(tert-Butyl-dimethyl-silanyloxy)-6-hydroxy-2,2,6-trimethyl-cyclohexanecarbaldehyde

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Chemical Property of 3-(tert-Butyl-dimethyl-silanyloxy)-6-hydroxy-2,2,6-trimethyl-cyclohexanecarbaldehyde

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Technology Process of 3-(tert-Butyl-dimethyl-silanyloxy)-6-hydroxy-2,2,6-trimethyl-cyclohexanecarbaldehyde

There total 8 articles about 3-(tert-Butyl-dimethyl-silanyloxy)-6-hydroxy-2,2,6-trimethyl-cyclohexanecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-(tert-Butyl-dimethyl-silanyloxy)-5,5-dimethyl-hept-6-enal oxime

: 209069-54-5
3-(tert-Butyl-dimethyl-silanyloxy)-6-hydroxy-2,2,6-trimethyl-cyclohexanecarbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: NaOCl / CH₂Cl₂; H₂O / Ambient temperature

2: 2.56 g / H₂, B(OH)3 / Pd-C / methanol; H₂O

3: 62 percent / tetrahydrofuran; diethyl ether / 6 h / Ambient temperature

4: 1) (COCl)2, DMSO, 2) Et₃N / 1) CH₂Cl₂, -78 deg C, 15 min, 2) CH₂Cl₂, 0 deg C, 20 min

With sodium hypochlorite; oxalyl dichloride; hydrogen; boric acid; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water;
DOI:10.1016/S0040-4020(98)00273-7

Reference yield:

: 209069-51-2
4-(tert-Butyl-dimethyl-silanyloxy)-5,5-dimethyl-hept-6-en-1-ol

: 209069-54-5
3-(tert-Butyl-dimethyl-silanyloxy)-6-hydroxy-2,2,6-trimethyl-cyclohexanecarbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: 1) (COCl)2, DMSO, 2) Et₃N / 1) CH₂Cl₂, 2) CH₂Cl₂

2: 3.09 g / NH₂OH*HCl, Et₃N

3: NaOCl / CH₂Cl₂; H₂O / Ambient temperature

4: 2.56 g / H₂, B(OH)3 / Pd-C / methanol; H₂O

5: 62 percent / tetrahydrofuran; diethyl ether / 6 h / Ambient temperature

6: 1) (COCl)2, DMSO, 2) Et₃N / 1) CH₂Cl₂, -78 deg C, 15 min, 2) CH₂Cl₂, 0 deg C, 20 min

With sodium hypochlorite; oxalyl dichloride; hydroxylamine hydrochloride; hydrogen; boric acid; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water;
DOI:10.1016/S0040-4020(98)00273-7

Reference yield:

: 1025825-82-4
4-(tert-Butyl-dimethyl-silanyloxy)-5,5-dimethyl-hept-6-enal

: 209069-54-5
3-(tert-Butyl-dimethyl-silanyloxy)-6-hydroxy-2,2,6-trimethyl-cyclohexanecarbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: 3.09 g / NH₂OH*HCl, Et₃N

2: NaOCl / CH₂Cl₂; H₂O / Ambient temperature

3: 2.56 g / H₂, B(OH)3 / Pd-C / methanol; H₂O

4: 62 percent / tetrahydrofuran; diethyl ether / 6 h / Ambient temperature

5: 1) (COCl)2, DMSO, 2) Et₃N / 1) CH₂Cl₂, -78 deg C, 15 min, 2) CH₂Cl₂, 0 deg C, 20 min

With sodium hypochlorite; oxalyl dichloride; hydroxylamine hydrochloride; hydrogen; boric acid; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water;
DOI:10.1016/S0040-4020(98)00273-7