3-(2-chlorophenyl)-N-(1-(3-methoxypropyl)-6-morpholino-2-(5-nitrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)propanamide

Base Information

• Chemical Name: 3-(2-chlorophenyl)-N-(1-(3-methoxypropyl)-6-morpholino-2-(5-nitrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)propanamide
• CAS No.: 1465825-68-6
• Molecular Formula: C₂₈H₃₀ClN₅O₆
• Molecular Weight: 568.029
• Mol file: 1465825-68-6.mol

Synonyms:3-(2-chlorophenyl)-N-(1-(3-methoxypropyl)-6-morpholino-2-(5-nitrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)propanamide

Chemical Property of 3-(2-chlorophenyl)-N-(1-(3-methoxypropyl)-6-morpholino-2-(5-nitrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)propanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-chlorophenyl)-N-(1-(3-methoxypropyl)-6-morpholino-2-(5-nitrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)propanamide

There total 5 articles about 3-(2-chlorophenyl)-N-(1-(3-methoxypropyl)-6-morpholino-2-(5-nitrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(2-chlorophenyl)propionyl chloride (52085-97-9) + C19H23N5O5 (1465826-20-3) → 3-(2-chlorophenyl)-N-(1-(3-methoxypropyl)-6-morpholino-2-(5-nitrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)propanamide (1465825-68-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.ejmech.2014.01.039

Reference yield:

C10H10FN3O5 (925702-74-5) → 3-(2-chlorophenyl)-N-(1-(3-methoxypropyl)-6-morpholino-2-(5-nitrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)propanamide (1465825-68-6)

Guidance literature:

Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

2: ammonium formate; palladium 10% on activated carbon / tetrahydrofuran; ethanol

3: acetic acid / tetrahydrofuran; ethanol; 1,4-dioxane / 20 °C

4: triethylamine / dichloromethane / 20 °C

With palladium 10% on activated carbon; ammonium formate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;

DOI:10.1016/j.ejmech.2014.01.039

Reference yield:

C14H20N4O6 (1465826-19-0) → 3-(2-chlorophenyl)-N-(1-(3-methoxypropyl)-6-morpholino-2-(5-nitrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)propanamide (1465825-68-6)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium formate; palladium 10% on activated carbon / tetrahydrofuran; ethanol

2: acetic acid / tetrahydrofuran; ethanol; 1,4-dioxane / 20 °C

3: triethylamine / dichloromethane / 20 °C

With palladium 10% on activated carbon; ammonium formate; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;

DOI:10.1016/j.ejmech.2014.01.039

upstream raw materials:

C₁₀H₁₀FN₃O₅

C₁₄H₂₀N₄O₆

3-(2-chlorophenyl)propionyl chloride

C₁₉H₂₃N₅O₅