2-<(4-bromo-2-fluorophenyl)methyl>-1,2,3,4-tetrahydro-4-(menthoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid

Base Information

Chemical Name:2-<(4-bromo-2-fluorophenyl)methyl>-1,2,3,4-tetrahydro-4-(menthoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid
CAS No.:129689-17-4
Molecular Formula:C₂₉H₃₁BrFNO₆
Molecular Weight:588.471
Hs Code.:

Synonyms:2-<(4-bromo-2-fluorophenyl)methyl>-1,2,3,4-tetrahydro-4-(menthoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid

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Chemical Property of 2-<(4-bromo-2-fluorophenyl)methyl>-1,2,3,4-tetrahydro-4-(menthoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid

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Technology Process of 2-<(4-bromo-2-fluorophenyl)methyl>-1,2,3,4-tetrahydro-4-(menthoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid

There total 5 articles about 2-<(4-bromo-2-fluorophenyl)methyl>-1,2,3,4-tetrahydro-4-(menthoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 129715-48-6
2-<(4-bromo-2-fluorophenyl)methyl>-1,2,3,4-tetrahydro-4-(menthoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid 1,1-dimethylethyl ester

: 129689-17-4
2-<(4-bromo-2-fluorophenyl)methyl>-1,2,3,4-tetrahydro-4-(menthoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 5h; Ambient temperature;
DOI:10.1021/jm00039a017

Reference yield:

: 703-59-3
homophthalic anhydride

: 129689-17-4
2-<(4-bromo-2-fluorophenyl)methyl>-1,2,3,4-tetrahydro-4-(menthoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 51 percent / triethylamine / 1.) THF, RT, 1 h, 2.) DMF, reflux, 15 h

2: 1.) lithium bis(trimethylsilyl)amide / 1.) THF, -78 deg C, 3 h, 2.) THF, RT, 30 min

3: 2.2 g / K₂CO₃ / dimethylformamide / 2 h / 85 °C

4: 94 percent / CF₃CO₂H / CH₂Cl₂ / 5 h / Ambient temperature

With potassium carbonate; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00039a017

Reference yield:

: (4-bromo-2-fluorophenyl)methanamine mono HCl salt

: 129689-17-4
2-<(4-bromo-2-fluorophenyl)methyl>-1,2,3,4-tetrahydro-4-(menthoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 51 percent / triethylamine / 1.) THF, RT, 1 h, 2.) DMF, reflux, 15 h

2: 1.) lithium bis(trimethylsilyl)amide / 1.) THF, -78 deg C, 3 h, 2.) THF, RT, 30 min

3: 2.2 g / K₂CO₃ / dimethylformamide / 2 h / 85 °C

4: 94 percent / CF₃CO₂H / CH₂Cl₂ / 5 h / Ambient temperature

With potassium carbonate; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00039a017