ethyl (4'R)-(+)-3-methyl-3-(4'-methyl-1'-cyclohexen-1'-yl)butanoate

Base Information

• Chemical Name: ethyl (4'R)-(+)-3-methyl-3-(4'-methyl-1'-cyclohexen-1'-yl)butanoate
• CAS No.: 679396-10-2
• Molecular Formula: C₁₄H₂₄O₂
• Molecular Weight: 224.343
• Mol file: 679396-10-2.mol

Synonyms:ethyl (4'R)-(+)-3-methyl-3-(4'-methyl-1'-cyclohexen-1'-yl)butanoate

Chemical Property of ethyl (4'R)-(+)-3-methyl-3-(4'-methyl-1'-cyclohexen-1'-yl)butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of ethyl (4'R)-(+)-3-methyl-3-(4'-methyl-1'-cyclohexen-1'-yl)butanoate

There total 2 articles about ethyl (4'R)-(+)-3-methyl-3-(4'-methyl-1'-cyclohexen-1'-yl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

syn-(-)-pulegol (22472-80-6) + Triethyl orthoacetate (78-39-7) → ethyl (4'R)-(+)-3-methyl-3-(4'-methyl-1'-cyclohexen-1'-yl)butanoate (679396-10-2)

Guidance literature:

With propionic acid; at 138 ℃; for 8h;

DOI:10.1021/jf035272a

Reference yield:

pulegone (89-82-7,90449-51-7) → ethyl (4'R)-(+)-3-methyl-3-(4'-methyl-1'-cyclohexen-1'-yl)butanoate (679396-10-2)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / ethanol; methanol; H₂O / 2 h / 20 °C

2: 86 percent / propionic acid / 8 h / 138 °C

With sodium tetrahydroborate; propionic acid; In methanol; ethanol; water;

DOI:10.1002/ejoc.200300800

Reference yield:

ethyl (4'R)-(+)-3-methyl-3-(4'-methyl-1'-cyclohexen-1'-yl)butanoate (679396-10-2) → (4R)-(+)-3-methyl-3-(4-methyl-1-cyclohexen-1-yl)butanoic acid (679396-11-3)

Guidance literature:

With potassium hydroxide; In ethanol; for 3h; Heating;

DOI:10.1021/jf035272a

upstream raw materials:

syn-(-)-pulegol

Triethyl orthoacetate

pulegone

Downstream raw materials:

(4R)-(+)-3-methyl-3-(4-methyl-1-cyclohexen-1-yl)butanoic acid

(5R,6S,8R)-(+)-4,4,8-trimethyl-1-oxaspiro[4.5]decane-2,6-diol