butyl-carbamic acid 1-allylcarbamoylmethyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl-methyl ester

Base Information

• Chemical Name: butyl-carbamic acid 1-allylcarbamoylmethyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl-methyl ester
• CAS No.: 1242185-47-2
• Molecular Formula: C₂₆H₃₀N₄O₄
• Molecular Weight: 462.549

Synonyms:butyl-carbamic acid 1-allylcarbamoylmethyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl-methyl ester

Chemical Property of butyl-carbamic acid 1-allylcarbamoylmethyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl-methyl ester

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Technology Process of butyl-carbamic acid 1-allylcarbamoylmethyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl-methyl ester

There total 1 articles about butyl-carbamic acid 1-allylcarbamoylmethyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.4%

N-allyl-2-[(3R)-3-(hydroxymethyl)-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl]acetamide (1012860-26-2) + n-butyl isocyanide (111-36-4) → butyl-carbamic acid 1-allylcarbamoylmethyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl-methyl ester (1242185-47-2)

Guidance literature:

In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.bmc.2010.06.010

Reference yield: 74.6%

butyl-carbamic acid 1-allylcarbamoylmethyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl-methyl ester (1242185-47-2) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → (R)-methyl 4-(2-(3-((butylcarbamoyloxy)methyl)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)acetamido)but-2-enoate

Guidance literature:

With Hoveyda-Grubbs catalyst second generation; In dichloromethane; at 100 ℃; for 2h; Microwave irradiation;

DOI:10.1016/j.bmc.2010.06.010

Reference yield: 69.0%

butyl-carbamic acid 1-allylcarbamoylmethyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl-methyl ester (1242185-47-2) + ethyl acrylate (140-88-5,9003-32-1) → C29H34N4O6 (1402828-83-4)

Guidance literature:

With Hoveyda-Grubbs catalyst second generation; In dichloromethane; at 100 ℃; for 1h; Microwave irradiation;

DOI:10.1002/cmdc.201200274

upstream raw materials:

N-allyl-2-[(3R)-3-(hydroxymethyl)-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl]acetamide

n-butyl isocyanide

Downstream raw materials:

C₂₉H₃₄N₄O₆

C₃₁H₃₈N₄O₆

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