Technology Process of Lumiracoxib
There total 23 articles about Lumiracoxib which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1-methyl-pyrrolidin-2-one; copper(l) iodide; potassium carbonate;
at 100 ℃;
DOI:10.1021/ol1010483
- Guidance literature:
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Multi-step reaction with 7 steps
1.1: NaH / dimethylformamide / 1 h / 0 - 4 °C
1.2: 91 percent / dimethylformamide / 20 h / 50 - 55 °C
2.1: HCl gas / ethyl acetate / 2.5 h / -5 - 0 °C
2.2: H2O / ethyl acetate / 36 h / 20 - 25 °C
3.1: 80 percent / H2SO4; EtOH; H2O / H2O / 4 h / 66 - 70 °C
4.1: 83 percent / Red-Al / toluene / 1.5 h / 60 - 62 °C
5.1: 82 percent / toluene / 80 - 90 °C
6.1: 80 percent / AlCl3 / 3 h / 170 °C
7.1: 90 percent / aq. NaOH / ethanol; H2O / Heating
With
hydrogenchloride; sodium hydroxide; aluminium trichloride; ethanol; sulfuric acid; water; sodium hydride; sodium bis(2-methoxyethoxy)aluminium dihydride;
In
ethanol; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
6.1: Friedel-Crafts cyclization;
DOI:10.1016/j.tet.2004.09.064