Technology Process of 5,6-epoxy-rapicone
There total 3 articles about 5,6-epoxy-rapicone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Rapicone;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 ℃;
for 0.5h;
With
Trimethyl borate;
In
tetrahydrofuran;
at -78 - 20 ℃;
With
dihydrogen peroxide; acetic acid;
In
tetrahydrofuran;
DOI:10.1016/j.tet.2012.04.010
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: iodine; silver trifluoroacetate / chloroform / 5 h / 20 °C
2.1: hexamethyldistannane; palladium diacetate; triphenylphosphine; lithium chloride / N,N-dimethyl-formamide / 21 h / 20 °C
2.2: 24 h / 20 °C
3.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C
3.2: -78 - 20 °C
With
iodine; hexamethyldistannane; palladium diacetate; silver trifluoroacetate; triphenylphosphine; lithium chloride; lithium diisopropyl amide;
In
tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2012.04.010
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hexamethyldistannane; palladium diacetate; triphenylphosphine; lithium chloride / N,N-dimethyl-formamide / 21 h / 20 °C
1.2: 24 h / 20 °C
2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C
2.2: -78 - 20 °C
With
hexamethyldistannane; palladium diacetate; triphenylphosphine; lithium chloride; lithium diisopropyl amide;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2012.04.010
