1-(2-((4-methoxyphenyl)amino)-3-oxo-3,4-dihydroquinoxalin-6-yl)-3-phenylthiourea

Base Information

Chemical Name:1-(2-((4-methoxyphenyl)amino)-3-oxo-3,4-dihydroquinoxalin-6-yl)-3-phenylthiourea
CAS No.:1627522-96-6
Molecular Formula:C₂₂H₁₉N₅O₂S
Molecular Weight:417.491
Hs Code.:

Synonyms:1-(2-((4-methoxyphenyl)amino)-3-oxo-3,4-dihydroquinoxalin-6-yl)-3-phenylthiourea

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Chemical Property of 1-(2-((4-methoxyphenyl)amino)-3-oxo-3,4-dihydroquinoxalin-6-yl)-3-phenylthiourea

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Technology Process of 1-(2-((4-methoxyphenyl)amino)-3-oxo-3,4-dihydroquinoxalin-6-yl)-3-phenylthiourea

There total 8 articles about 1-(2-((4-methoxyphenyl)amino)-3-oxo-3,4-dihydroquinoxalin-6-yl)-3-phenylthiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1627522-94-4
7-amino-3-((4-methoxyphenyl)amino)quinoxalin-2(1H)-one

: 103-72-0
phenyl isothiocyanate

: 1627522-96-6
1-(2-((4-methoxyphenyl)amino)-3-oxo-3,4-dihydroquinoxalin-6-yl)-3-phenylthiourea

Guidance literature:: In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bioorg.2014.05.010

Reference yield:

: 1627522-93-3
3-((4-methoxyphenyl)amino)-7-nitroquinoxalin-2(1H)-one

: 1627522-96-6
1-(2-((4-methoxyphenyl)amino)-3-oxo-3,4-dihydroquinoxalin-6-yl)-3-phenylthiourea

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; methanol / 24 h / 40 °C

2: tetrahydrofuran / 20 °C

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol;
DOI:10.1016/j.bioorg.2014.05.010

Reference yield:

: 95-54-5
1,2-diamino-benzene

: 1627522-96-6
1-(2-((4-methoxyphenyl)amino)-3-oxo-3,4-dihydroquinoxalin-6-yl)-3-phenylthiourea

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogenchloride / water / 2 h / Reflux

2: potassium nitrate; sulfuric acid / 20 °C

3: trichlorophosphate / 6 h / Reflux

4: isopropyl alcohol / 20 °C

5: hydrogenchloride / water / 50 °C

6: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; methanol / 24 h / 40 °C

7: tetrahydrofuran / 20 °C

With hydrogenchloride; sulfuric acid; palladium 10% on activated carbon; hydrogen; potassium nitrate; trichlorophosphate; In tetrahydrofuran; methanol; water; isopropyl alcohol;
DOI:10.1016/j.bioorg.2014.05.010