(2R,3S)-2-Acetoxy-3-benzyloxycarbonylamino-3-(pyridin-2-yl)propionic acid ethyl ester

Base Information

Chemical Name:(2R,3S)-2-Acetoxy-3-benzyloxycarbonylamino-3-(pyridin-2-yl)propionic acid ethyl ester
CAS No.:259729-63-0
Molecular Formula:C₂₀H₂₂N₂O₆
Molecular Weight:386.404
Hs Code.:

Synonyms:(2R,3S)-2-Acetoxy-3-benzyloxycarbonylamino-3-(pyridin-2-yl)propionic acid ethyl ester

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Chemical Property of (2R,3S)-2-Acetoxy-3-benzyloxycarbonylamino-3-(pyridin-2-yl)propionic acid ethyl ester

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Technology Process of (2R,3S)-2-Acetoxy-3-benzyloxycarbonylamino-3-(pyridin-2-yl)propionic acid ethyl ester

There total 1 articles about (2R,3S)-2-Acetoxy-3-benzyloxycarbonylamino-3-(pyridin-2-yl)propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 621-84-1
O-benzyl carbamate

: 108-24-7
acetic anhydride

: 90922-50-2,259729-55-0
(E)-ethyl 3-(N-oxypyridin-2-yl)acrylate

: 3-acetoxy-2-benzyloxycarbonylamino-3-pyridin-2-yl-propionic acid ethyl ester

: 259729-63-0
(2R,3S)-2-Acetoxy-3-benzyloxycarbonylamino-3-(pyridin-2-yl)propionic acid ethyl ester

Guidance literature:: O-benzyl carbamate; (E)-ethyl 3-(N-oxypyridin-2-yl)acrylate; With Hydroquinone 1,4-phthalazinediyl diether; potassium dioxotetrahydroxoosmate(VI); tert-butylhypochlorite; In propan-1-ol; sodium hydroxide; at 20 ℃; for 24h;

acetic anhydride; With hydrogen; acetic acid; nickel; at 20 ℃; for 24h; under 750.06 Torr;
DOI:10.1055/s-1999-2973

Reference yield:

: 259729-63-0
(2R,3S)-2-Acetoxy-3-benzyloxycarbonylamino-3-(pyridin-2-yl)propionic acid ethyl ester

: (2R,3S)-3-Benzoylamino-2-hydroxy-3-pyridin-2-yl-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / H₂ / 5 percent Pd/C / methanol / 24 h / 20 °C / 750.06 Torr

2: HCl; H₂O / 4 h / Heating

3: NaOH; H₂O / 30 h / 0 - 20 °C

With hydrogenchloride; sodium hydroxide; water; hydrogen; palladium on activated charcoal; In methanol; 1: Hydrogenolysis / 2: Hydrolysis / 3: Acylation;
DOI:10.1055/s-1999-2973