(3-iodo-benzylsulfanyl)-acetic acid

Base Information

• Chemical Name: (3-iodo-benzylsulfanyl)-acetic acid
• CAS No.: 867202-89-9
• Molecular Formula: C₉H₉IO₂S
• Molecular Weight: 308.14
• Mol file: 867202-89-9.mol

Synonyms:(3-iodo-benzylsulfanyl)-acetic acid

Chemical Property of (3-iodo-benzylsulfanyl)-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-iodo-benzylsulfanyl)-acetic acid

There total 4 articles about (3-iodo-benzylsulfanyl)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C8H9IN2S (763077-07-2) + chloroacetic acid (79-11-8) → (3-iodo-benzylsulfanyl)-acetic acid (867202-89-9)

Guidance literature:

C₈H₉IN₂S; With sodium hydroxide; In water; at 80 ℃; for 1h;

chloroacetic acid; for 2h; Reflux;

DOI:10.1111/cbdd.12083

Reference yield:

(3-Iodo-benzylsulfanyl)-acetic acid methyl ester (867202-90-2) → (3-iodo-benzylsulfanyl)-acetic acid (867202-89-9)

Guidance literature:

(3-Iodo-benzylsulfanyl)-acetic acid methyl ester; With methanol; lithium hydroxide; water; at 20 ℃;

With hydrogenchloride; water; In methanol; pH=< 4;

Reference yield:

3-iodobenzylalcohol (57455-06-8) → (3-iodo-benzylsulfanyl)-acetic acid (867202-89-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogen bromide / water / 60 °C

1.2: 0.5 h / Reflux

2.1: sodium hydroxide / 1 h / 80 °C

2.2: 2 h / Reflux

With hydrogen bromide; sodium hydroxide; In water;

DOI:10.1016/j.bmcl.2011.12.099

upstream raw materials:

(3-Iodo-benzylsulfanyl)-acetic acid methyl ester

C₈H₉IN₂S

chloroacetic acid

3-iodobenzylalcohol

Downstream raw materials:

2-(3-Iodo-phenylmethanesulfinyl)-acetamide

2-(3-Iodo-benzylsulfanyl)-acetamide

(3-Iodo-benzylsulfanyl)-acetic acid methyl ester

C₉H₉IO₃S