Technology Process of 6-oxo-N-phenyl-1-(prop-2-ynyl)-1,6-dihydropyridine-2-carboxamide
There total 5 articles about 6-oxo-N-phenyl-1-(prop-2-ynyl)-1,6-dihydropyridine-2-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydrogencarbonate;
In
dichloromethane;
at 20 ℃;
for 1h;
DOI:10.1021/ol0706307
- Guidance literature:
-
Multi-step reaction with 2 steps
1: oxalyl chloride / CH2Cl2; dimethylformamide / 0 °C
2: NaHCO3 / CH2Cl2 / 1 h / 20 °C
With
oxalyl dichloride; sodium hydrogencarbonate;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol0706307
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sulfuric acid / 10 h / Heating
2: 11.6 g / potassium carbonate; lithium bromide; tetrabutylammonium bromide / H2O; toluene / 0.33 h / 80 °C
3: lithium hydroxide monohydrate / H2O; tetrahydrofuran / 0.17 h / 0 °C
4: oxalyl chloride / CH2Cl2; dimethylformamide / 0 °C
5: NaHCO3 / CH2Cl2 / 1 h / 20 °C
With
lithium hydroxide; oxalyl dichloride; sulfuric acid; tetrabutylammomium bromide; sodium hydrogencarbonate; potassium carbonate; lithium bromide;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol0706307
