N-carbobenzoxy(imbutyloxycarbonyl)-His-(O-tert-butyl)-Asp-(O-tert-butyl)-Ser-Gly-pentachlorophenyl ester

Base Information

Chemical Name:N-carbobenzoxy(imbutyloxycarbonyl)-His-(O-tert-butyl)-Asp-(O-tert-butyl)-Ser-Gly-pentachlorophenyl ester
CAS No.:84866-25-1
Molecular Formula:C₄₂H₅₁Cl₅N₆O₁₂
Molecular Weight:1009.16
Hs Code.:

Synonyms:N-carbobenzoxy(imbutyloxycarbonyl)-His-(O-tert-butyl)-Asp-(O-tert-butyl)-Ser-Gly-pentachlorophenyl ester

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Chemical Property of N-carbobenzoxy(imbutyloxycarbonyl)-His-(O-tert-butyl)-Asp-(O-tert-butyl)-Ser-Gly-pentachlorophenyl ester

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Technology Process of N-carbobenzoxy(imbutyloxycarbonyl)-His-(O-tert-butyl)-Asp-(O-tert-butyl)-Ser-Gly-pentachlorophenyl ester

There total 5 articles about N-carbobenzoxy(imbutyloxycarbonyl)-His-(O-tert-butyl)-Asp-(O-tert-butyl)-Ser-Gly-pentachlorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: (O-tert-butyl)-Asp-(O-tert-butyl)-Ser-Gly-pentachlorophenyl ester hydrochloride

: 32675-94-8
N^α-CBZ-N^im-BOC-L-histidine

: 84866-25-1
N-carbobenzoxy(imbutyloxycarbonyl)-His-(O-tert-butyl)-Asp-(O-tert-butyl)-Ser-Gly-pentachlorophenyl ester

Guidance literature:: In tetrahydrofuran;
DOI:10.1002/jps.2600711217

Reference yield:

: (O-tert-butyl)-Ser-Gly-pentachlorophenyl ester hydrochloride

: 84866-25-1
N-carbobenzoxy(imbutyloxycarbonyl)-His-(O-tert-butyl)-Asp-(O-tert-butyl)-Ser-Gly-pentachlorophenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / N-methylmorpholine / tetrahydrofuran

2: 78 percent / hydrogen, hydrogen chloride / Pd/C

3: 71 percent / tetrahydrofuran

With 4-methyl-morpholine; hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1002/jps.2600711217

Reference yield:

: 1676-75-1
N-benzyloxycarbonyl-O-t-butyl-L-serine

: 84866-25-1
N-carbobenzoxy(imbutyloxycarbonyl)-His-(O-tert-butyl)-Asp-(O-tert-butyl)-Ser-Gly-pentachlorophenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) N-methylmorpholine, isobutyl chlorocarbonate / 1.) tetrahydrofuran, 20 deg C, 30 min, 2.) ice-temperature -> room temperature, overnight

2: 93 percent / hydrogen, hydrogen chloride / 10percent palladium-charcoal / methanol; acetic acid / 0.17 h

3: 67 percent / N-methylmorpholine / tetrahydrofuran

4: 78 percent / hydrogen, hydrogen chloride / Pd/C

5: 71 percent / tetrahydrofuran

With 4-methyl-morpholine; hydrogenchloride; hydrogen; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid;
DOI:10.1002/jps.2600711217