(R)-5-[(E)-3-(4-Methoxy-benzyloxy)-1-triisopropylsilanyloxymethyl-propenyl]-2-(2-nitro-phenyl)-cyclohex-2-enone

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Chemical Name:(R)-5-[(E)-3-(4-Methoxy-benzyloxy)-1-triisopropylsilanyloxymethyl-propenyl]-2-(2-nitro-phenyl)-cyclohex-2-enone
CAS No.:482351-25-7
Molecular Formula:C₃₃H₄₅NO₆Si
Molecular Weight:579.809
Hs Code.:

Synonyms:(R)-5-[(E)-3-(4-Methoxy-benzyloxy)-1-triisopropylsilanyloxymethyl-propenyl]-2-(2-nitro-phenyl)-cyclohex-2-enone

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Chemical Property of (R)-5-[(E)-3-(4-Methoxy-benzyloxy)-1-triisopropylsilanyloxymethyl-propenyl]-2-(2-nitro-phenyl)-cyclohex-2-enone

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Technology Process of (R)-5-[(E)-3-(4-Methoxy-benzyloxy)-1-triisopropylsilanyloxymethyl-propenyl]-2-(2-nitro-phenyl)-cyclohex-2-enone

There total 3 articles about (R)-5-[(E)-3-(4-Methoxy-benzyloxy)-1-triisopropylsilanyloxymethyl-propenyl]-2-(2-nitro-phenyl)-cyclohex-2-enone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 76074-18-5
trimethyl-(2-nitro-phenyl)-stannane

: 793723-97-4
(R)-2-Iodo-5-[(E)-3-(4-methoxy-benzyloxy)-1-triisopropylsilanyloxymethyl-propenyl]-cyclohex-2-enone

: 482351-25-7
(R)-5-[(E)-3-(4-Methoxy-benzyloxy)-1-triisopropylsilanyloxymethyl-propenyl]-2-(2-nitro-phenyl)-cyclohex-2-enone

Guidance literature:: With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; copper(l) iodide; triphenyl-arsane; In N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2004.06.141

Reference yield:

: [[2-(7R)-1,4-dioxaspiro[4,5]dec-7-yl-4-[(4-methoxyphenyl)methoxy]-2-butenyl]oxy]tris-(1-methylethyl)silane

: 482351-25-7
(R)-5-[(E)-3-(4-Methoxy-benzyloxy)-1-triisopropylsilanyloxymethyl-propenyl]-2-(2-nitro-phenyl)-cyclohex-2-enone

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4.08 g / dl-CSA / acetone / 48 h / 20 °C

2.1: 2,2,6,6-tetramethylpiperidine; BuLi; TMSCl / hexane; tetrahydrofuran / 2 h / -78 °C

2.2: diallyl carbonate; Pd₂(dba)3*CHCl₃ / acetonitrile / 12 h / 20 °C

2.3: I₂; DMAP / CH₂Cl₂

3.1: 100 percent / Pd₂(dba)3*CHCl₃; Ph₃As; CuI / dimethylformamide

With 2,2,6,6-tetramethyl-piperidine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; copper(l) iodide; n-butyllithium; chloro-trimethyl-silane; triphenyl-arsane; DL-10-camphorsulfonic acid; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; acetone; 2.2: Saegusa-Ito reaction / 3.1: Stille coupling;
DOI:10.1016/j.tet.2004.06.141

Reference yield:

: 482351-10-0
(3R)-3-[(1E)-3-[(4-methoxyphenyl)methoxy]-1-[[[tris-(1-methylethyl)silyl]oxy]methyl]-1-propenyl]cyclohexanone

: 482351-25-7
(R)-5-[(E)-3-(4-Methoxy-benzyloxy)-1-triisopropylsilanyloxymethyl-propenyl]-2-(2-nitro-phenyl)-cyclohex-2-enone

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,2,6,6-tetramethylpiperidine; BuLi; TMSCl / hexane; tetrahydrofuran / 2 h / -78 °C

1.2: diallyl carbonate; Pd₂(dba)3*CHCl₃ / acetonitrile / 12 h / 20 °C

1.3: I₂; DMAP / CH₂Cl₂

2.1: 100 percent / Pd₂(dba)3*CHCl₃; Ph₃As; CuI / dimethylformamide

With 2,2,6,6-tetramethyl-piperidine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; copper(l) iodide; n-butyllithium; chloro-trimethyl-silane; triphenyl-arsane; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; 1.2: Saegusa-Ito reaction / 2.1: Stille coupling;
DOI:10.1016/j.tet.2004.06.141