{(3S,4R)-3-(4-chloro-phenyl)-4-[1-((S)-5-fluoro-pyridin-2-yloxy)-ethyl]-pyrrolidin-1-yl}-piperidin-4-yl-methanone

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Chemical Name:{(3S,4R)-3-(4-chloro-phenyl)-4-[1-((S)-5-fluoro-pyridin-2-yloxy)-ethyl]-pyrrolidin-1-yl}-piperidin-4-yl-methanone
CAS No.:1268692-82-5
Molecular Formula:C₂₃H₂₇ClFN₃O₂
Molecular Weight:431.938
Hs Code.:

Synonyms:{(3S,4R)-3-(4-chloro-phenyl)-4-[1-((S)-5-fluoro-pyridin-2-yloxy)-ethyl]-pyrrolidin-1-yl}-piperidin-4-yl-methanone

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Chemical Property of {(3S,4R)-3-(4-chloro-phenyl)-4-[1-((S)-5-fluoro-pyridin-2-yloxy)-ethyl]-pyrrolidin-1-yl}-piperidin-4-yl-methanone

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Technology Process of {(3S,4R)-3-(4-chloro-phenyl)-4-[1-((S)-5-fluoro-pyridin-2-yloxy)-ethyl]-pyrrolidin-1-yl}-piperidin-4-yl-methanone

There total 6 articles about {(3S,4R)-3-(4-chloro-phenyl)-4-[1-((S)-5-fluoro-pyridin-2-yloxy)-ethyl]-pyrrolidin-1-yl}-piperidin-4-yl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₃₅ClFN₃O₄

: 1268692-82-5
{(3S,4R)-3-(4-chloro-phenyl)-4-[1-((S)-5-fluoro-pyridin-2-yloxy)-ethyl]-pyrrolidin-1-yl}-piperidin-4-yl-methanone

Guidance literature:: C₂₈H₃₅ClFN₃O₄; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With sodium hydroxide; In dichloromethane; water; at 20 ℃; pH=10;

Reference yield:

: 1115961-72-2
1-(1-benzyl-2,5-dihydro-1H-pyrrol-3-yl)-ethanone

: 1268692-82-5
{(3S,4R)-3-(4-chloro-phenyl)-4-[1-((S)-5-fluoro-pyridin-2-yloxy)-ethyl]-pyrrolidin-1-yl}-piperidin-4-yl-methanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetylacetonatobis(ethylene)rhodium(I); (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / water; methanol / 8 h / 55 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

3.1: di-tert-butyl-diazodicarboxylate / PPh₃ polymer bound / tetrahydrofuran

4.1: N-ethyl-N,N-diisopropylamine; carbonochloridic acid 1-chloro-ethyl ester / toluene / 1 h / 100 °C

5.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 1 h / 20 °C

5.2: 20 °C

6.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

6.2: 20 °C / pH 10

With lithium aluminium tetrahydride; carbonochloridic acid 1-chloro-ethyl ester; di-tert-butyl-diazodicarboxylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; acetylacetonatobis(ethylene)rhodium(I); (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; In tetrahydrofuran; methanol; dichloromethane; water; toluene;

Reference yield:

: 1115962-21-4
(R)-1-[(3R,4S)-1-benzyl-4-(4-chloro-phenyl)-pyrrolidin-3-yl]-ethanol

: 1268692-82-5
{(3S,4R)-3-(4-chloro-phenyl)-4-[1-((S)-5-fluoro-pyridin-2-yloxy)-ethyl]-pyrrolidin-1-yl}-piperidin-4-yl-methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: di-tert-butyl-diazodicarboxylate / PPh₃ polymer bound / tetrahydrofuran

2.1: N-ethyl-N,N-diisopropylamine; carbonochloridic acid 1-chloro-ethyl ester / toluene / 1 h / 100 °C

3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 1 h / 20 °C

3.2: 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.2: 20 °C / pH 10

With carbonochloridic acid 1-chloro-ethyl ester; di-tert-butyl-diazodicarboxylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; PPh₃ polymer bound; In tetrahydrofuran; dichloromethane; toluene;