N-(2'-N,N-dimethylcarbamoylthio-3'-formyl-5'-nitrobenzyl)-3,9-dithia-6-monoazaundecane

Base Information

• Chemical Name: N-(2'-N,N-dimethylcarbamoylthio-3'-formyl-5'-nitrobenzyl)-3,9-dithia-6-monoazaundecane
• CAS No.: 420787-38-8
• Molecular Formula: C₁₉H₂₉N₃O₄S₃
• Molecular Weight: 459.655
• Mol file: 420787-38-8.mol

Synonyms:N-(2'-N,N-dimethylcarbamoylthio-3'-formyl-5'-nitrobenzyl)-3,9-dithia-6-monoazaundecane

Chemical Property of N-(2'-N,N-dimethylcarbamoylthio-3'-formyl-5'-nitrobenzyl)-3,9-dithia-6-monoazaundecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2'-N,N-dimethylcarbamoylthio-3'-formyl-5'-nitrobenzyl)-3,9-dithia-6-monoazaundecane

There total 4 articles about N-(2'-N,N-dimethylcarbamoylthio-3'-formyl-5'-nitrobenzyl)-3,9-dithia-6-monoazaundecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

N-(2'-N,N-dimethylthiocarbamoyloxy-3'-formyl-5'-nitrobenzyl)-3,9-dithia-6-monoazaundecane (420787-37-7) → N-(2'-N,N-dimethylcarbamoylthio-3'-formyl-5'-nitrobenzyl)-3,9-dithia-6-monoazaundecane (420787-38-8)

Guidance literature:

In toluene; for 6h; Heating;

DOI:10.1021/jo0162843

Reference yield:

3-(chloromethyl)-2-hydroxy-5-nitrobenzaldehyde (16644-30-7) → N-(2'-N,N-dimethylcarbamoylthio-3'-formyl-5'-nitrobenzyl)-3,9-dithia-6-monoazaundecane (420787-38-8)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran / 15 h / 0 - 20 °C

2: Et₃N / dimethylformamide / 15 h / 0 - 20 °C

3: 32 percent / toluene / 6 h / Heating

With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jo0162843

Reference yield:

N,N-bis(2-(ethylthio)ethyl)amine (81526-29-6) → N-(2'-N,N-dimethylcarbamoylthio-3'-formyl-5'-nitrobenzyl)-3,9-dithia-6-monoazaundecane (420787-38-8)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran / 15 h / 0 - 20 °C

2: Et₃N / dimethylformamide / 15 h / 0 - 20 °C

3: 32 percent / toluene / 6 h / Heating

With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jo0162843

upstream raw materials:

N-(2'-N,N-dimethylthiocarbamoyloxy-3'-formyl-5'-nitrobenzyl)-3,9-dithia-6-monoazaundecane

3-(chloromethyl)-2-hydroxy-5-nitrobenzaldehyde

N,N-bis(2-(ethylthio)ethyl)amine

N-(2'-hydroxy-3'-formyl-5'-nitrobenzyl)-3,9-dithia-6-monoazaundecane

Downstream raw materials:

(2'-mercapto-3'-formyl-5'-nitrobenzyl)-3,9-dithia-6-monoazaundecane