3-{4-[(4-chloro-phenyl)-hydrazinocarbonylmethyl-sulfamoyl]-phenyl}-N-(3-dimethylamino-propyl)-propionamide

Base Information

Chemical Name:3-{4-[(4-chloro-phenyl)-hydrazinocarbonylmethyl-sulfamoyl]-phenyl}-N-(3-dimethylamino-propyl)-propionamide
CAS No.:415963-51-8
Molecular Formula:C₂₂H₃₀ClN₅O₄S
Molecular Weight:496.03
Hs Code.:

3-{4-[(4-chloro-phenyl)-hydrazinocarbonylmethyl-sulfamoyl]-phenyl}-<i>N</i>-(3-dimethylamino-propyl)-propionamide

Synonyms:3-{4-[(4-chloro-phenyl)-hydrazinocarbonylmethyl-sulfamoyl]-phenyl}-N-(3-dimethylamino-propyl)-propionamide

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Chemical Property of 3-{4-[(4-chloro-phenyl)-hydrazinocarbonylmethyl-sulfamoyl]-phenyl}-N-(3-dimethylamino-propyl)-propionamide

Chemical Property:

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Technology Process of 3-{4-[(4-chloro-phenyl)-hydrazinocarbonylmethyl-sulfamoyl]-phenyl}-N-(3-dimethylamino-propyl)-propionamide

There total 6 articles about 3-{4-[(4-chloro-phenyl)-hydrazinocarbonylmethyl-sulfamoyl]-phenyl}-N-(3-dimethylamino-propyl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 415963-50-7
((4-chloro-phenyl)-{4-[2-(3-dimethylamino-propylcarbamoyl)-ethyl]-benzenesulfonyl}-amino)-acetic acid methyl ester

: 415963-51-8
3-{4-[(4-chloro-phenyl)-hydrazinocarbonylmethyl-sulfamoyl]-phenyl}-N-(3-dimethylamino-propyl)-propionamide

Guidance literature:: With hydrazine hydrate; In methanol; at 20 ℃;
DOI:10.1021/jm050645f

Reference yield:

: 374537-95-8
methyl 3-[4-(chlorosulfonyl)-phenyl]propanoate

: 415963-51-8
3-{4-[(4-chloro-phenyl)-hydrazinocarbonylmethyl-sulfamoyl]-phenyl}-N-(3-dimethylamino-propyl)-propionamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 82.4 percent / pyridine / 0 - 20 °C

2.1: aq. NaOH / dioxane / 20 °C

3.1: isobutyl chloroformate; N-methylmorpholine / tetrahydrofuran / 0.5 h / -25 °C

3.2: tetrahydrofuran / -25 - 20 °C

4.1: triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 20 °C

4.2: tetrahydrofuran / 20 °C

5.1: hydrazine hydrate / methanol / 20 °C

With 4-methyl-morpholine; pyridine; sodium hydroxide; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; methanol;
DOI:10.1021/jm050645f

Reference yield:

: 871827-59-7
3-{4-[(4-chloroanilino)sulfonyl]phenyl}propanoic acid

: 415963-51-8
3-{4-[(4-chloro-phenyl)-hydrazinocarbonylmethyl-sulfamoyl]-phenyl}-N-(3-dimethylamino-propyl)-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: isobutyl chloroformate; N-methylmorpholine / tetrahydrofuran / 0.5 h / -25 °C

1.2: tetrahydrofuran / -25 - 20 °C

2.1: triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 20 °C

2.2: tetrahydrofuran / 20 °C

3.1: hydrazine hydrate / methanol / 20 °C

With 4-methyl-morpholine; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; isobutyl chloroformate; In tetrahydrofuran; methanol;
DOI:10.1021/jm050645f