1-((benzyloxy)methyl)-4-((R,Z)-3-methyl-6-((2S,5S)-2-methyl-5-(2-((triethylsilyl)oxy)propan-2-yl)tetrahydrofuran-2-yl)-6-((triethylsilyl)oxy)hex-2-en-1-yl)-2-nitro-1H-pyrrole

Base Information

Chemical Name:1-((benzyloxy)methyl)-4-((R,Z)-3-methyl-6-((2S,5S)-2-methyl-5-(2-((triethylsilyl)oxy)propan-2-yl)tetrahydrofuran-2-yl)-6-((triethylsilyl)oxy)hex-2-en-1-yl)-2-nitro-1H-pyrrole
CAS No.:1514894-33-7
Molecular Formula:C₃₉H₆₆N₂O₆Si₂
Molecular Weight:715.134
Hs Code.:

1-((benzyloxy)methyl)-4-((R,Z)-3-methyl-6-((2S,5S)-2-methyl-5-(2-((triethylsilyl)oxy)propan-2-yl)tetrahydrofuran-2-yl)-6-((triethylsilyl)oxy)hex-2-en-1-yl)-2-nitro-1H-pyrrole

Synonyms:1-((benzyloxy)methyl)-4-((R,Z)-3-methyl-6-((2S,5S)-2-methyl-5-(2-((triethylsilyl)oxy)propan-2-yl)tetrahydrofuran-2-yl)-6-((triethylsilyl)oxy)hex-2-en-1-yl)-2-nitro-1H-pyrrole

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Chemical Property of 1-((benzyloxy)methyl)-4-((R,Z)-3-methyl-6-((2S,5S)-2-methyl-5-(2-((triethylsilyl)oxy)propan-2-yl)tetrahydrofuran-2-yl)-6-((triethylsilyl)oxy)hex-2-en-1-yl)-2-nitro-1H-pyrrole

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Technology Process of 1-((benzyloxy)methyl)-4-((R,Z)-3-methyl-6-((2S,5S)-2-methyl-5-(2-((triethylsilyl)oxy)propan-2-yl)tetrahydrofuran-2-yl)-6-((triethylsilyl)oxy)hex-2-en-1-yl)-2-nitro-1H-pyrrole

There total 15 articles about 1-((benzyloxy)methyl)-4-((R,Z)-3-methyl-6-((2S,5S)-2-methyl-5-(2-((triethylsilyl)oxy)propan-2-yl)tetrahydrofuran-2-yl)-6-((triethylsilyl)oxy)hex-2-en-1-yl)-2-nitro-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1514894-18-8
2-(1-((benzyloxy)methyl)-5-nitro-1H-pyrrol-3-yl)acetaldehyde

: 5-(((5R)-5-((2S,5S)-2-methyl-5-(2-((triethylsilyl)oxy)propan-2-yl)tetrahydrofuran-2-yl)-5-((triethylsilyl)oxy)pentan-2-yl)sulfonyl)-1-phenyl-1H-tetrazole

: 1514894-33-7
1-((benzyloxy)methyl)-4-((R,Z)-3-methyl-6-((2S,5S)-2-methyl-5-(2-((triethylsilyl)oxy)propan-2-yl)tetrahydrofuran-2-yl)-6-((triethylsilyl)oxy)hex-2-en-1-yl)-2-nitro-1H-pyrrole

: 1-((benzyloxy)methyl)-4-((R,E)-3-methyl-6-((2S,5S)-2-methyl-5-(2-((triethylsilyl)oxy)propan-2-yl)tetrahydrofuran-2-yl)-6-((triethylsilyl)oxy)hex-2-en-1-yl)-2-nitro-1H-pyrrole

Guidance literature:: 5-(((5R)-5-((2S,5S)-2-methyl-5-(2-((triethylsilyl)oxy)propan-2-yl)tetrahydrofuran-2-yl)-5-((triethylsilyl)oxy)pentan-2-yl)sulfonyl)-1-phenyl-1H-tetrazole; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.25h;

2-(1-((benzyloxy)methyl)-5-nitro-1H-pyrrol-3-yl)acetaldehyde; In tetrahydrofuran; at -78 - 20 ℃; Overall yield = 42 %;
DOI:10.1021/ol403246j

Reference yield:

: 1514894-14-4
1-benzyloxymethyl-2-nitro-4-vinylpyrrole

: 1514894-33-7
1-((benzyloxy)methyl)-4-((R,Z)-3-methyl-6-((2S,5S)-2-methyl-5-(2-((triethylsilyl)oxy)propan-2-yl)tetrahydrofuran-2-yl)-6-((triethylsilyl)oxy)hex-2-en-1-yl)-2-nitro-1H-pyrrole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfuric acid / acetonitrile; water / 0.33 h

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C

2.2: -78 - 20 °C

With sulfuric acid; sodium hexamethyldisilazane; In tetrahydrofuran; water; acetonitrile; 2.1: |Julia-Kocienski Olefination / 2.2: |Julia-Kocienski Olefination;
DOI:10.1021/ol403246j

Reference yield:

: 1514894-10-0
1-benzyloxymethyl-2-nitro-4-iodopyrrole

: 1514894-33-7
1-((benzyloxy)methyl)-4-((R,Z)-3-methyl-6-((2S,5S)-2-methyl-5-(2-((triethylsilyl)oxy)propan-2-yl)tetrahydrofuran-2-yl)-6-((triethylsilyl)oxy)hex-2-en-1-yl)-2-nitro-1H-pyrrole

Guidance literature:: Multi-step reaction with 3 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide

2.1: sulfuric acid / acetonitrile; water / 0.33 h

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C

3.2: -78 - 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sulfuric acid; sodium hexamethyldisilazane; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile; 1.1: |Stille Cross Coupling / 3.1: |Julia-Kocienski Olefination / 3.2: |Julia-Kocienski Olefination;
DOI:10.1021/ol403246j