diethyl 4-(4-fluorobenzoyl)-5-(4-nitrophenyl)-1H-pyrrole-2,2(5H)-dicarboxylate

Base Information

Chemical Name:diethyl 4-(4-fluorobenzoyl)-5-(4-nitrophenyl)-1H-pyrrole-2,2(5H)-dicarboxylate
CAS No.:1325732-05-5
Molecular Formula:C₂₃H₂₁FN₂O₇
Molecular Weight:456.427
Hs Code.:

Synonyms:diethyl 4-(4-fluorobenzoyl)-5-(4-nitrophenyl)-1H-pyrrole-2,2(5H)-dicarboxylate

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Chemical Property of diethyl 4-(4-fluorobenzoyl)-5-(4-nitrophenyl)-1H-pyrrole-2,2(5H)-dicarboxylate

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Technology Process of diethyl 4-(4-fluorobenzoyl)-5-(4-nitrophenyl)-1H-pyrrole-2,2(5H)-dicarboxylate

There total 4 articles about diethyl 4-(4-fluorobenzoyl)-5-(4-nitrophenyl)-1H-pyrrole-2,2(5H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 6829-40-9
aminomalonic acid diethyl ester

: 555-16-8
4-nitrobenzaldehdye

: 54012-23-6
1-(4-fluorophenyl)prop-2-yn-1-one

: 1325732-05-5
diethyl 4-(4-fluorobenzoyl)-5-(4-nitrophenyl)-1H-pyrrole-2,2(5H)-dicarboxylate

Guidance literature:: With (R)-3,3'-bis(9-anthracenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; In toluene; at 50 ℃; for 58h; optical yield given as %ee; enantioselective reaction; Molecular sieve;
DOI:10.1021/ol201898x

Reference yield:

: 3798-61-6,179249-16-2
1-(4-fluorophenyl)prop-2-yn-1-ol

: 1325732-05-5
diethyl 4-(4-fluorobenzoyl)-5-(4-nitrophenyl)-1H-pyrrole-2,2(5H)-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: manganese(IV) oxide / dichloromethane / 0 - 20 °C

2: (R)-3,3'-bis(9-anthracenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate / toluene / 58 h / 50 °C / Molecular sieve

With (R)-3,3'-bis(9-anthracenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; manganese(IV) oxide; In dichloromethane; toluene;
DOI:10.1021/ol201898x

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 1325732-05-5
diethyl 4-(4-fluorobenzoyl)-5-(4-nitrophenyl)-1H-pyrrole-2,2(5H)-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 - 20 °C / Inert atmosphere

2.1: potassium carbonate / methanol / 2 h / 20 °C

3.1: manganese(IV) oxide / dichloromethane / 0 - 20 °C

4.1: (R)-3,3'-bis(9-anthracenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate / toluene / 58 h / 50 °C / Molecular sieve

With (R)-3,3'-bis(9-anthracenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; manganese(IV) oxide; n-butyllithium; potassium carbonate; In tetrahydrofuran; methanol; hexane; dichloromethane; toluene;
DOI:10.1021/ol201898x