(S)-ethyl 2-(cyclohex-1-en-1-ylmethyl)-3,3,3-trifluoro-2-hydroxypropanoate

Base Information

• Chemical Name: (S)-ethyl 2-(cyclohex-1-en-1-ylmethyl)-3,3,3-trifluoro-2-hydroxypropanoate
• CAS No.: 918549-00-5
• Molecular Formula: C₁₂H₁₇F₃O₃
• Molecular Weight: 266.26
• Mol file: 918549-00-5.mol

Synonyms:(S)-ethyl 2-(cyclohex-1-en-1-ylmethyl)-3,3,3-trifluoro-2-hydroxypropanoate

Chemical Property of (S)-ethyl 2-(cyclohex-1-en-1-ylmethyl)-3,3,3-trifluoro-2-hydroxypropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (S)-ethyl 2-(cyclohex-1-en-1-ylmethyl)-3,3,3-trifluoro-2-hydroxypropanoate

There total 5 articles about (S)-ethyl 2-(cyclohex-1-en-1-ylmethyl)-3,3,3-trifluoro-2-hydroxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl-3,3,3-trifluoropyruvate (13081-18-0) + methylenecyclohexane (1192-37-6) → (S)-ethyl 2-(cyclohex-1-en-1-ylmethyl)-3,3,3-trifluoro-2-hydroxypropanoate (918549-00-5)

Guidance literature:

With silver hexafluoroantimonate; [(R)-(+)2,2’-bis(diphenylphosphino)-1,1’-binaphthyl]palladium(II) chloride; at 25 ℃; for 0.5h; Solvent; Temperature; Time; Concentration; enantioselective reaction; Catalytic behavior; Inert atmosphere; Ionic liquid; Green chemistry;

DOI:10.1039/c3gc40875b

Reference yield:

ethyl-3,3,3-trifluoropyruvate (13081-18-0) + methylenecyclohexane (1192-37-6) → (S)-ethyl 2-(cyclohex-1-en-1-ylmethyl)-3,3,3-trifluoro-2-hydroxypropanoate (918549-00-5) + (R)-ethyl 2-(cyclohex-1-en-1-ylmethyl)-3,3,3-trifluoro-2-hydroxypropanoate

Guidance literature:

Further Variations:; Catalysts; time; Product distribution;

DOI:10.1021/jo062023n

Reference yield:

1-methylcyclohex-1-ene (591-49-1) + ethyl-3,3,3-trifluoropyruvate (13081-18-0) → (1'R,2S)-ethyl 3,3,3-trifluoro-2-hydroxy-2-(2'-methylcyclohex-2'-en-1'-yl)propanoate + (S)-ethyl 2-(cyclohex-1-en-1-ylmethyl)-3,3,3-trifluoro-2-hydroxypropanoate (918549-00-5) + (R)-ethyl 2-(cyclohex-1-en-1-ylmethyl)-3,3,3-trifluoro-2-hydroxypropanoate + (1'S,2S)-ethyl 3,3,3-trifluoro-2-hydroxy-2-(2'-methylenecyclohex-1'-yl)propanoate

Guidance literature:

Further Variations:; Catalysts; time; Product distribution;

DOI:10.1021/jo062023n

upstream raw materials:

1-methylcyclohex-1-ene

ethyl-3,3,3-trifluoropyruvate

methylenecyclohexane