methyl 7,7-diphenyl-4-thiophen-3-yl-7λ⁵-phosphinino[2,3-b]thiophene-6-carboxylate

Base Information

• Chemical Name: methyl 7,7-diphenyl-4-thiophen-3-yl-7λ⁵-phosphinino[2,3-b]thiophene-6-carboxylate
• CAS No.: 1448325-92-5
• Molecular Formula: C₂₅H₁₉O₂PS₂
• Molecular Weight: 446.53

Synonyms:methyl 7,7-diphenyl-4-thiophen-3-yl-7λ⁵-phosphinino[2,3-b]thiophene-6-carboxylate

Chemical Property of methyl 7,7-diphenyl-4-thiophen-3-yl-7λ⁵-phosphinino[2,3-b]thiophene-6-carboxylate

Chemical Property:

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Technology Process of methyl 7,7-diphenyl-4-thiophen-3-yl-7λ⁵-phosphinino[2,3-b]thiophene-6-carboxylate

There total 4 articles about methyl 7,7-diphenyl-4-thiophen-3-yl-7λ⁵-phosphinino[2,3-b]thiophene-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

3-ethynylthiophene (67237-53-0) + [diphenyl(thiophen-2-yl)phosphonio](methoxycarbonyl) (1448325-77-6) → methyl 7,7-diphenyl-4-thiophen-3-yl-7λ5-phosphinino[2,3-b]thiophene-6-carboxylate (1448325-92-5) + methyl 1-phenyl-1-thiophen-2-yl-4-thiophen-3-yl-1λ5-phosphinoline-2-carboxylate (1448325-93-6)

Guidance literature:

In dichloromethane;

DOI:10.1016/j.tet.2013.06.066

Reference yield:

(2-methoxy-2-oxoethyl)(diphenyl)thiophen-2-ylphosphonium bromide (1448325-72-1) → methyl 7,7-diphenyl-4-thiophen-3-yl-7λ5-phosphinino[2,3-b]thiophene-6-carboxylate (1448325-92-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium methylate / methanol / 2 h / 0 - 5 °C

2: methanol / 1 h / 0 - 5 °C

3: dichloromethane

With sodium methylate; In methanol; dichloromethane;

DOI:10.1016/j.tet.2013.06.066

Reference yield:

diphenyl(2-thienyl)phosphine (61157-16-2) → methyl 7,7-diphenyl-4-thiophen-3-yl-7λ5-phosphinino[2,3-b]thiophene-6-carboxylate (1448325-92-5)

Guidance literature:

Multi-step reaction with 4 steps

1: acetonitrile / 2 h / Reflux

2: sodium methylate / methanol / 2 h / 0 - 5 °C

3: methanol / 1 h / 0 - 5 °C

4: dichloromethane

With sodium methylate; In methanol; dichloromethane; acetonitrile;

DOI:10.1016/j.tet.2013.06.066

upstream raw materials:

methyl [diphenyl(thiophen-2-yl)-λ⁵-phosphanylidene]acetate

3-ethynylthiophene

[diphenyl(thiophen-2-yl)phosphonio](methoxycarbonyl)

diphenyl(2-thienyl)phosphine

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