Technology Process of 5-fluoro-2-hydroxy-4-methoxybenzaldehyde
There total 4 articles about 5-fluoro-2-hydroxy-4-methoxybenzaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2,4-dimethoxy-5-fluorobenzaldehyde;
With
boron trichloride;
In
dichloromethane;
at 0 - 20 ℃;
for 24h;
Inert atmosphere;
With
water;
In
dichloromethane;
at 0 ℃;
Inert atmosphere;
DOI:10.1016/j.tet.2011.03.059
- Guidance literature:
-
With
2-amino-4-trifluoromethylbenzoic acid; palladium diacetate; toluene-4-sulfonic acid; 1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate; acetic acid;
at 90 ℃;
for 24h;
Sealed tube;
DOI:10.1021/acs.orglett.7b02906
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: titanium tetrachloride / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
1.2: 0.5 h / 0 °C / Inert atmosphere
1.3: Inert atmosphere
2.1: boron trichloride / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere
2.2: 0 °C / Inert atmosphere
With
boron trichloride; titanium tetrachloride;
In
dichloromethane;
DOI:10.1016/j.tet.2011.03.059
