(1R,2S)-2-phenylcyclohexyl 2-((R)-3-(4-chlorophenyl)-4,5-dihydroisoxazol-5-yl)acetate

Base Information

Chemical Name:(1R,2S)-2-phenylcyclohexyl 2-((R)-3-(4-chlorophenyl)-4,5-dihydroisoxazol-5-yl)acetate
CAS No.:1309794-07-7
Molecular Formula:C₂₃H₂₄ClNO₃
Molecular Weight:397.901
Hs Code.:

Synonyms:(1R,2S)-2-phenylcyclohexyl 2-((R)-3-(4-chlorophenyl)-4,5-dihydroisoxazol-5-yl)acetate

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Chemical Property of (1R,2S)-2-phenylcyclohexyl 2-((R)-3-(4-chlorophenyl)-4,5-dihydroisoxazol-5-yl)acetate

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Technology Process of (1R,2S)-2-phenylcyclohexyl 2-((R)-3-(4-chlorophenyl)-4,5-dihydroisoxazol-5-yl)acetate

There total 4 articles about (1R,2S)-2-phenylcyclohexyl 2-((R)-3-(4-chlorophenyl)-4,5-dihydroisoxazol-5-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1309794-03-3
(1R,2S)-2-phenylcyclohexyl but-3-enoate

: 28123-63-9
4-chlorobenzohydroximoyl chloride

: 1309794-07-7
(1R,2S)-2-phenylcyclohexyl 2-((R)-3-(4-chlorophenyl)-4,5-dihydroisoxazol-5-yl)acetate

: (1R,2S)-2-phenylcyclohexyl 2-((S)-3-(4-chlorophenyl)-4,5-dihydroisoxazol-5-yl)acetate

Guidance literature:: With triethylamine; In dichloromethane; for 24h;

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 1309794-07-7
(1R,2S)-2-phenylcyclohexyl 2-((R)-3-(4-chlorophenyl)-4,5-dihydroisoxazol-5-yl)acetate

: (1R,2S)-2-phenylcyclohexyl 2-((S)-3-(4-chlorophenyl)-4,5-dihydroisoxazol-5-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium acetate / methanol / 16 h / Reflux

2: N-chloro-succinimide / N,N-dimethyl-formamide / 16 h / Cooling with ice bath; Heating

3: triethylamine / dichloromethane / 24 h

With N-chloro-succinimide; hydroxylamine hydrochloride; sodium acetate; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 98919-68-7
(1R,2S)-trans-2-phenylcyclohexanol

: 1309794-07-7
(1R,2S)-2-phenylcyclohexyl 2-((R)-3-(4-chlorophenyl)-4,5-dihydroisoxazol-5-yl)acetate

: (1R,2S)-2-phenylcyclohexyl 2-((S)-3-(4-chlorophenyl)-4,5-dihydroisoxazol-5-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene; water / 3 h / Dean-Stark trap; Reflux

2: triethylamine / dichloromethane / 24 h

With toluene-4-sulfonic acid; triethylamine; In dichloromethane; water; toluene;