10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-N₇-[(1E)-(dimethylamino)methylene]-N₂-[(4-fluoro-3-methylphenyl)methyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2,7(6H)-dicarboxamide

Base Information

• Chemical Name: 10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-N₇-[(1E)-(dimethylamino)methylene]-N₂-[(4-fluoro-3-methylphenyl)methyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2,7(6H)-dicarboxamide
• CAS No.: 1380665-30-4
• Molecular Formula: C₂₉H₃₆FN₇O₆
• Molecular Weight: 597.647

Synonyms:10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-N₇-[(1E)-(dimethylamino)methylene]-N₂-[(4-fluoro-3-methylphenyl)methyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2,7(6H)-dicarboxamide

Chemical Property of 10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-N₇-[(1E)-(dimethylamino)methylene]-N₂-[(4-fluoro-3-methylphenyl)methyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2,7(6H)-dicarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Useful:

Technology Process of 10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-N₇-[(1E)-(dimethylamino)methylene]-N₂-[(4-fluoro-3-methylphenyl)methyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2,7(6H)-dicarboxamide

There total 5 articles about 10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-N₇-[(1E)-(dimethylamino)methylene]-N₂-[(4-fluoro-3-methylphenyl)methyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2,7(6H)-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-N2-[(4-fluoro-3-methylphenyl)methyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2,7(6H)-dicarboxamide (1380665-28-0) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-N7-[(1E)-(dimethylamino)methylene]-N2-[(4-fluoro-3-methylphenyl)methyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2,7(6H)-dicarboxamide (1380665-30-4)

Guidance literature:

at 120 ℃; for 2h;

Reference yield:

N-[7-[(acetyloxy)methyl]-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-carbamic acid phenylmethyl ester (1380665-18-8) → 10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-N7-[(1E)-(dimethylamino)methylene]-N2-[(4-fluoro-3-methylphenyl)methyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2,7(6H)-dicarboxamide (1380665-30-4)

Guidance literature:

Multi-step reaction with 7 steps

1: hydrogen / palladium 10% on activated carbon / methanol

2: 4-methyl-morpholine; HATU / 1 h

3: sodium carbonate / acetonitrile; water; methanol / 1 h

4: Dess-Martin periodane / dichloromethane

5: sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 0.75 h

6: pyridine; di-tert-butyl dicarbonate; ammonium bicarbonate / 1,4-dioxane / 18 h

7: 2 h / 120 °C

With 4-methyl-morpholine; pyridine; sodium chlorite; sodium dihydrogenphosphate; di-tert-butyl dicarbonate; hydrogen; sodium carbonate; ammonium bicarbonate; Dess-Martin periodane; HATU; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; water; acetonitrile; tert-butyl alcohol;

Reference yield:

7-[(acetyloxy)methyl]-10-amino-N-[(4-fluoro-3-methylphenyl)methyl]-4,6,7,8,9,10-hexahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2-carboxamide (1380665-19-9) → 10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-N7-[(1E)-(dimethylamino)methylene]-N2-[(4-fluoro-3-methylphenyl)methyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2,7(6H)-dicarboxamide (1380665-30-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 4-methyl-morpholine; HATU / 1 h

2: sodium carbonate / acetonitrile; water; methanol / 1 h

3: Dess-Martin periodane / dichloromethane

4: sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 0.75 h

5: pyridine; di-tert-butyl dicarbonate; ammonium bicarbonate / 1,4-dioxane / 18 h

6: 2 h / 120 °C

With 4-methyl-morpholine; pyridine; sodium chlorite; sodium dihydrogenphosphate; di-tert-butyl dicarbonate; sodium carbonate; ammonium bicarbonate; Dess-Martin periodane; HATU; In 1,4-dioxane; methanol; dichloromethane; water; acetonitrile; tert-butyl alcohol;

upstream raw materials:

10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-N₂-[(4-fluoro-3-methylphenyl)methyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2,7(6H)-dicarboxamide

N,N-dimethyl-formamide dimethyl acetal

N-[7-[(acetyloxy)methyl]-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-carbamic acid phenylmethyl ester

7-[(acetyloxy)methyl]-10-amino-N-[(4-fluoro-3-methylphenyl)methyl]-4,6,7,8,9,10-hexahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepine-2-carboxamide

Downstream raw materials:

N-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-4-oxo-7-(4H-1,2,4-triazol-3-yl)-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N₁,N₁-dimethyl-ethanediamide

N'-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-7-(1H-1,2,4-triazol-3-yl)-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N,N-dimethyl-ethanediamide

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