methyl 5-chloro-2-{[(2-oxo-2-{[3-(1H-pyrazol-4-yl)phenyl]amino}ethoxy)acetyl]amino}benzoate

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Chemical Name:methyl 5-chloro-2-{[(2-oxo-2-{[3-(1H-pyrazol-4-yl)phenyl]amino}ethoxy)acetyl]amino}benzoate
CAS No.:1190222-99-1
Molecular Formula:C₂₁H₁₉ClN₄O₅
Molecular Weight:442.859
Hs Code.:

Synonyms:methyl 5-chloro-2-{[(2-oxo-2-{[3-(1H-pyrazol-4-yl)phenyl]amino}ethoxy)acetyl]amino}benzoate

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Chemical Property of methyl 5-chloro-2-{[(2-oxo-2-{[3-(1H-pyrazol-4-yl)phenyl]amino}ethoxy)acetyl]amino}benzoate

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Technology Process of methyl 5-chloro-2-{[(2-oxo-2-{[3-(1H-pyrazol-4-yl)phenyl]amino}ethoxy)acetyl]amino}benzoate

There total 5 articles about methyl 5-chloro-2-{[(2-oxo-2-{[3-(1H-pyrazol-4-yl)phenyl]amino}ethoxy)acetyl]amino}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1190222-99-1
methyl 5-chloro-2-{[(2-oxo-2-{[3-(1H-pyrazol-4-yl)phenyl]amino}ethoxy)acetyl]amino}benzoate

Guidance literature:

Reference yield: 52.0%

: 1190223-00-7
tert-butyl 4-(3-{[(2-{[4-chloro-2-(methoxycarbonyl)phenyl]amino}-2-oxoethoxy)acetyl]amino}phenyl)-1H-pyrazole-1-carboxylate

: 1190222-99-1
methyl 5-chloro-2-{[(2-oxo-2-{[3-(1H-pyrazol-4-yl)phenyl]amino}ethoxy)acetyl]amino}benzoate

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 17h;
DOI:10.1016/j.bmcl.2017.11.016

Reference yield:

: 1103929-71-0
(2-{[4-chloro-2-(methoxycarbonyl)phenyl]amino}-2-oxoethoxy)acetic acid

: 1190222-99-1
methyl 5-chloro-2-{[(2-oxo-2-{[3-(1H-pyrazol-4-yl)phenyl]amino}ethoxy)acetyl]amino}benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl acetamide / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / tetrahydrofuran / 12 h / Inert atmosphere; Reflux

3: hydrogenchloride / ethyl acetate / 17 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl acetamide; ethyl acetate; 2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2017.11.016