tert-butyl [4-(4-(2-(Trifluoromethyl)phenylethynyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate

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Chemical Name:tert-butyl [4-(4-(2-(Trifluoromethyl)phenylethynyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate
CAS No.:1191423-30-9
Molecular Formula:C₃₀H₃₄F₃N₅O₃Si
Molecular Weight:597.712
Hs Code.:

Synonyms:tert-butyl [4-(4-(2-(Trifluoromethyl)phenylethynyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate

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Chemical Property of tert-butyl [4-(4-(2-(Trifluoromethyl)phenylethynyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate

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Technology Process of tert-butyl [4-(4-(2-(Trifluoromethyl)phenylethynyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate

There total 6 articles about tert-butyl [4-(4-(2-(Trifluoromethyl)phenylethynyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1191423-17-2
C₃₀H₃₈F₃N₅O₃Si

: 1191423-30-9
tert-butyl [4-(4-(2-(Trifluoromethyl)phenylethynyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate

Guidance literature:: C₃₀H₃₈F₃N₅O₃Si; With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;

With manganese(IV) oxide;
DOI:10.1016/j.bmcl.2009.07.099

Reference yield:

: 4-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrole-2-carbaldehyde

: 1191423-30-9
tert-butyl [4-(4-(2-(Trifluoromethyl)phenylethynyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 100 °C / Inert atmosphere

2.1: ethanol / 50 °C / Inert atmosphere

3.1: dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethanol; N,N-dimethyl-formamide; 1.1: Sonogashira coupling / 2.1: Pictet-Spengler cyclisation;
DOI:10.1248/cpb.59.579

Reference yield:

: 1191422-95-3
4-(2-(trifluoromethyl)phenylethynyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-carbaldehyde

: 1191423-30-9
tert-butyl [4-(4-(2-(Trifluoromethyl)phenylethynyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / 50 °C / Inert atmosphere

2.1: dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethanol; 1.1: Pictet-Spengler cyclisation;
DOI:10.1248/cpb.59.579