3-(3-oxoisoxazolidin-4-yl)-2-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one

Base Information

• Chemical Name: 3-(3-oxoisoxazolidin-4-yl)-2-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one
• CAS No.: 1448530-39-9
• Molecular Formula: C₂₂H₂₃N₃O₆S
• Molecular Weight: 457.507

Synonyms:3-(3-oxoisoxazolidin-4-yl)-2-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one

Chemical Property of 3-(3-oxoisoxazolidin-4-yl)-2-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one

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Technology Process of 3-(3-oxoisoxazolidin-4-yl)-2-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one

There total 3 articles about 3-(3-oxoisoxazolidin-4-yl)-2-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl 2-(3,4,5-trimethoxybenzamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (72625-07-1) + 4-amino-3-isoxazolidone (68-39-3,68-41-7,339-72-0,4834-58-6) → 3-(3-oxoisoxazolidin-4-yl)-2-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one (1448530-39-9)

Guidance literature:

With phosphorus pentoxide; trichlorophosphate; for 5h; Reflux;

DOI:10.1016/j.ejmech.2013.04.055

Reference yield:

ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (4506-71-2) → 3-(3-oxoisoxazolidin-4-yl)-2-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one (1448530-39-9)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 3 h / Reflux

2: phosphorus pentoxide; trichlorophosphate / 5 h / Reflux

With phosphorus pentoxide; trichlorophosphate; In benzene;

DOI:10.1016/j.ejmech.2013.04.055

Reference yield:

3,4,5-Trimethoxybenzoyl chloride (4521-61-3) → 3-(3-oxoisoxazolidin-4-yl)-2-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one (1448530-39-9)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 3 h / Reflux

2: phosphorus pentoxide; trichlorophosphate / 5 h / Reflux

With phosphorus pentoxide; trichlorophosphate; In benzene;

DOI:10.1016/j.ejmech.2013.04.055

upstream raw materials:

ethyl 2-(3,4,5-trimethoxybenzamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

4-amino-3-isoxazolidone

ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

3,4,5-Trimethoxybenzoyl chloride

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