N⁵-(5-aminopentyl)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]-triazine-5,7-diamine trifluoroacetate

Base Information

• Chemical Name: N⁵-(5-aminopentyl)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]-triazine-5,7-diamine trifluoroacetate
• CAS No.: 1262940-19-1
• Molecular Formula: C₂HF₃O₂*C₁₃H₁₈N₈O
• Molecular Weight: 416.363

Synonyms:N⁵-(5-aminopentyl)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]-triazine-5,7-diamine trifluoroacetate

Chemical Property of N⁵-(5-aminopentyl)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]-triazine-5,7-diamine trifluoroacetate

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Technology Process of N⁵-(5-aminopentyl)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]-triazine-5,7-diamine trifluoroacetate

There total 2 articles about N⁵-(5-aminopentyl)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]-triazine-5,7-diamine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-tert-butoxycarbonylamino-1-aminopentane (51644-96-3) → N5-(5-aminopentyl)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]-triazine-5,7-diamine trifluoroacetate (1262940-19-1)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1.5 h / 70 °C / Sealed tube

2: dichloromethane

With N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;

DOI:10.1021/acs.jmedchem.8b00860

Reference yield:

5-tert-butoxycarbonylamino-1-aminopentane (51644-96-3) + 7-amino-2-(furan-2-yl)-5-phenoxy-[1,2,4]triazolo[1,5-a][1,3,5]triazine (139179-53-6) → N5-(5-aminopentyl)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]-triazine-5,7-diamine trifluoroacetate (1262940-19-1)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 3 h / 120 °C / sealed tube

2: dichloromethane / 3 h / 20 °C

In ethanol; dichloromethane;

DOI:10.1021/jm101349u

Reference yield: 2.0%

N5-(5-aminopentyl)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]-triazine-5,7-diamine trifluoroacetate (1262940-19-1) + 4-fluorosulfonylbenzoyl chloride (402-55-1) → 4-((5-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino)pentyl)carbamoyl)benzenesulfonyl fluoride

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 70 ℃; for 2.5h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.8b00860

upstream raw materials:

5-tert-butoxycarbonylamino-1-aminopentane

7-amino-2-(furan-2-yl)-5-phenoxy-[1,2,4]triazolo[1,5-a][1,3,5]triazine

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